Cold-induced thermogenesis in adults from Siberia and Western Europe

Completed

Conditions: Energy balance. Overweight.
10018424

Registration Number: NL-OMON51034

Lead Sponsor: Maastricht University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 16

Inclusion Criteria

Signed informed consent, White western European, Healthy Man or Woman, Age 18 *
70 years at the start of the study, BMI * 18.5 and <35 kg/m2, Participants must
meet all the of the following: same sex, within ± 8 years of age, and within ±
5 % body mass and ± 5 % height of a previous cold-acclimated participant

Exclusion Criteria

Smoking.
Active uncontrolled cardiovascular disease.
Raynaud*s disease.
Cold-acclimated, such as takes daily cold baths, or works in a refrigerated
environment, within 1 month previous to the start of the study.
Abuse of alcohol or drugs.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters/endpoints:<br /><br>* The energy expenditure during the whole-body cold exposure</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Exploratory parameters:<br /><br><br /><br>o Shivering activity (using surface electromyography) during the cold exposure<br /><br>o Core (using a telemetric pill) and skin temperatures (using iButtons) during<br /><br>the cold exposure<br /><br>o Thermal sensation and comfort (via questionnaires) during the cold exposure<br /><br>o Heart rate (via polar chest strap) and blood pressure (via automatic blood<br /><br>pressure device) during the cold exposure<br /><br>o 6 days daily-living measurement of skin temperature (iButtons) and physical<br /><br>activity (actigraph)<br /><br>o Cold-induced vasodilation (assessed during cold-finger test)<br /><br>o Body composition (via skinfold thickness and deuterium dilution)<br /><br>o Glucose, triglycerides and cholesterol (via fingertip capillary blood sample)</p><br>