Effects of cold exposure on energy expenditure by brown adipose tissue in humans
- Conditions
- Healthy male volunteers
- Registration Number
- JPRN-UMIN000009005
- Lead Sponsor
- Tenshi College, School of Nursing and Nutrition, Department of Nutrition
- Brief Summary
ineteen adult males subjects with low activities of brown adipose tissue were randomly assigned to two groups: one (n=9) was exposed to cold at 15-17 C for 2 h every day, while the other (n=10) maintained their usual daily life without cold exposure. After 6 wk under exposure to cold, cold-induced thermogenesis and BAT activity assessed by FDG-PET/CT increased compared with those at 0 wk and also with those in the control group without exposure. During the 6-wk period, body fat mass decreased more in the cold-exposed group than the control group. Moreover, the change in body fat mass negatively correlated with those in the BAT activity and cold-induced thermogenesis. These findings suggest that chronic cold exposure recruits brown adipose tissue, thereby contributing to the reduction of body fat in humans.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 20
Not provided
Body mass index >=30
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method