The effect of cold acclimation on brown adipose tissue.
Completed
- Conditions
- Brown adipose tissueCold acclimationSkeletal muscleNon-shivering thermogenesis
- Registration Number
- NL-OMON20696
- Lead Sponsor
- Maastricht University Medical Centre + (MUMC+)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. BMI 18-25;
2. Age 18-30;
Exclusion Criteria
1. Diabetes Mellitus;
2. Females: Pregnancy;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Standard uptake values (SUVs) of FDG of active brown adipose tissue with the PET/CT-scans, one time prior and one time post the cold acclimation period (2x 2hour);<br /><br>2. Energy expenditure with indirect calorimetry, one time prior, half way and one time post the cold acclimation period (3x 3hour);<br /><br>3. Skeletal muscle mitochondrial uncoupling with the muscle biopsy, one time before and one time post the cold acclimation period (2x 30minutes). <br>BRITE cell recruitment with the fat biopsy, one time prior and one time post the cold acclimation period (2x 30minutes).
- Secondary Outcome Measures
Name Time Method 1. Body temperatures (core and skin temperatures) with iButtons and a telemetric pill, one time prior, half way and one time post the cold acclimation period;<br /><br>2. Skin perfusion with laser Doppler flowmetry, one time prior, half way and one time post the cold acclimation period;<br /><br>3. Blood parameters, among others insulin, glucose, free fatty acids and thyroid hormones, one time prior, half way and post the cold acclimation period;<br /><br>4. Body composition with a DXA-scan, one time prior and post the cold acclimation period.