The effect of cold acclimation on human brown adipose tissue and skeletal muscle uncoupling
Completed
- Conditions
- geennvt
- Registration Number
- NL-OMON35672
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Healthy lean (BMI 18-25) adults
Age: 18-30 years
Females: on 1 oral contraceptive (Microgynon 30 / levonorgestrel/ehinylestradiol)
Caucasians
Exclusion Criteria
Diabetes mellitus
Females: pregnancy
Participate in physical activity more than 2x/week
Use of Beta-blockers
Cardiovascular diseases
Asthma or other obstructive pulmonary diseases
Elevated fasting blood glucose level (> 5.6 mmol/L)
Participation in earlier research that included a PET/CT-scan
Radiation therapy due to medical treatment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Standard uptake values (SUV's) of FDG of active brown adipose tissue<br /><br>Energy expenditure<br /><br>Skeletal muscle mitochondrial uncoupling<br /><br>BRITE cell recruitment</p><br>
- Secondary Outcome Measures
Name Time Method <p>Body temperatures (core and skin temperatures)<br /><br>Skin perfusion<br /><br>Body composition<br /><br>Blood parameters</p><br>