Effecten van een hoge eiwitinname bij kinderen met obesitas.
Not yet recruiting
- Conditions
- obesity, metabolic syndrome, insulin sensitivity
- Registration Number
- NL-OMON24325
- Lead Sponsor
- Sophia Children's Hospital - Erasmus MC Rotterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
1. Boys & girls;
2. Obesity (BMI-SDS>2.3);
Exclusion Criteria
1. Obesity that is caused by a somatic treatable disorder;
2. Use of systemic steroids.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The change in body composition (body fat%, fat-free mass, fat mass, fat-free mass index, fat mass index , waist and hip circumference, waist:hip ratio) in obese children who consumed a high protein diet for 4 weeks. Measurements will be performed with a DEXA-scan and the deuterium dilution technique.
- Secondary Outcome Measures
Name Time Method Whole body protein turnover, gluconeogenesis, energy expenditure, insulin sensitivity, and markers of dyslipidemia and oxidative stress, measured with stable isotoop techniques.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie protein-induced improvements in insulin sensitivity in pediatric obesity?
How does high protein intake compare to standard nutritional therapy for metabolic syndrome in obese children?
Which biomarkers correlate with weight loss outcomes in high protein dietary interventions for pediatric obesity?
What adverse events are associated with high protein diets in children with metabolic syndrome and obesity?
Are there synergistic effects when combining high protein intake with GLP-1 receptor agonists in pediatric obesity management?