Clinical study on the effectiveness and mechanism of acupuncture combined with donepezil for mild Alzheimer's disease
- Conditions
- Alzheimer's disease
- Registration Number
- ITMCTR2100004654
- Lead Sponsor
- Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
This study is designed to include participants aged 50-80 years with diagnosis of mild AD according to NIA-AA criteria or with a CDR score between 0.5 and 1. The subject included are required to have no history of taking anti-dementia drugs systematically (donepezil excluded), and at least one reliable caretaker who can accompany the subject during treatment is also needed.
Individuals will be excluded if they have dementia caused by other diseases other than AD, such as cer-ebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease; a history of psychological disorders (DSM-IV criteria); uncorrectable visual or auditory impairment that hampers the completion of related examination. Patients could not participate this study if they are allergic to acupuncture or pace-maker installed. Pre-menopausal women will also be excluded.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Alzheimer's disease Assessment Scale-Cognitive Subscale;
- Secondary Outcome Measures
Name Time Method functional Magnetic Resonance Imaging, fMRI;Activities of Daily Living Scales;magnetoencephalography, MEG;