Schizophrenia as a disorder of social cognition: an fMRI study in adolescents

Completed

• Conditions: schizophrenia; psychosis; 10039628

• Registration Number: NL-OMON39432
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

- adolescents-between 16-21 years of age and UHR + controls (16-31 years)
- Dutch speaking
- For patients: only atypical medication

Exclusion Criteria

- intellectual impairment (i.e., IQ < 80)
- contraindications to fMRI
- drugs or alcohol use 48 hours prior to scanning
- For controls: history of psychosis and use of medication

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the hemodynamic response (i.e. change in blood<br /><br>flow) in response to the investment and the repayment phase of the trust game.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameters consists of the behavioural data, i.e. the<br /><br>actual amounts invested during the three games. We also want to obtain insight<br /><br>in the relationship of activities, stress and self-appraisal to the occurrence<br /><br>of a psychosis. The social variables like Theory of Mind (Reading the Mind in<br /><br>the Eyes task) and SoMi will be included in the analysis.</p><br>