A Pilot Study on the Clinical Significance of Cerebrovascular Autoregulation Monitoring during Non-Cardiac Anaesthesia

Not Applicable

Completed

• Conditions: Post-operative recovery, mortality, and morbidity from major surgery; cerebrovascular autoregulation; Anaesthesiology - Anaesthetics

• Registration Number: ACTRN12613000825752
• Lead Sponsor: iverpool Hospital, South West Sydney Local Health District

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-07-26
• Study Completion: 2017-02-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 142

Inclusion Criteria

Adult patients presenting for non-cardiac surgery, who fulfil the following:
* age greater than or equal to 60 years old
* American Society of Anesthesiologists (ASA) physical status 3 or 4
* elective major surgery, defined as operations expected to last greater than or equal to 2hours, and post-operative hospital stay of greater than or equal to 2 nights
* General anaesthesia with or without major regional anaesthesia
* have standard anaesthetic management, which includes the following monitoring: arterial catheter pressure waveform, end-tidal volatile agent concentrations, and non-invasive processed electroencephalography (Bispectral index, BIS)

Exclusion Criteria

* Certain non-cardiac surgical operations, due to the surgical site either adjacent or interfering with the near infrared spectroscopy optode placement, or of the recording electrodes of the depth of anaesthesia monitor, will be ineligible for recruitment. These are intracranial and extracranial neurosurgical and head/neck operations
* unable to consent
* surgery with wake-up testing
* Patients who are not fluent in English, as they may be unable to complete questionnaires designed for Post-operative Quality of Recovery testing relevant to post-operative recovery
* Patients, who at the discretion of the treating anaesthetist, receives a total intravenous general anaesthetic (TIVA) technique instead of an inhalational general anaesthesia
* previous enrolment in the BALANCED depth of anaesthesia and patient outcomes study

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of recovery of the cognitive domain at Day 3, as measured using the Post-Operative Quality of Recovery Score[Day 3 post-operative]