Neuropsychological and Behavioral Testing in Younger Patients With Cancer

Active, not recruiting

• Conditions: Childhood Malignant Neoplasm
• Interventions: Procedure: Cognitive Assessment; Other: Quality-of-Life Assessment

• Registration Number: NCT00772200
• Lead Sponsor: Children's Oncology Group

Brief Summary

This research trial studies neuropsychological (learning, remembering or thinking) and behavioral outcomes in children and adolescents with cancer by collecting information over time from a series of tests.

Detailed Description

PRIMARY OBJECTIVES:

I. To institute procedures to ensure a consistent, streamlined, and efficient administration of the neuropsychological/behavioral tests in a cooperative group setting in order to maximize compliance with a standardized assessment battery conducted at 3 standardized time points.

OUTLINE:

Parent and child participants complete the COG Standard Neuropsychological and Behavioral Battery at approximately 9, 30, and 60 months post-diagnosis in a 1-2 hour testing session conducted by a neuropsychologist or psychologist. The Battery consists of measures of intelligence, processing speed, attention, memory, language preference, behavioral/social/emotional function, executive function, adaptive function, and quality of life.

Study Timeline

• Study First Submitted: 2008-10-14
• Study First Submitted QC: 2008-10-14
• Study First Posted: 2008-10-15
• Study Start: 2009-02-27
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-22
• Last Update Posted: 2024-08-26

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

• The patient must be currently be enrolled or plan to be enrolled on a COG therapeutic study that aims to examine neuropsychological, social, emotional, and/or behavioral functioning
• The patient must have receptive and expressive language skills in English, French, or Spanish; if a patient meets these criteria but the parent/guardian speaks a language other than English, French, or Spanish, the patient may still be enrolled and tested, and the parent-report measures should be omitted
• All patients and/or their parents or legal guardians must sign a written informed consent
• All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Exclusion Criteria

• Patients with a history of moderate to profound intellectual disability (i.e. intelligence quotient [IQ] =< 55) are not eligible for enrollment; PLEASE NOTE: Children with a prior history of attention deficit hyperactivity disorder (ADHD) or a specific learning disability (e.g., dyslexia) are eligible for this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Observational (neuropsychological and behavioral tests)	Quality-of-Life Assessment	Parent and child participants complete the COG Standard Neuropsychological and Behavioral Battery at approximately 9, 30, and 60 months post-diagnosis in a 1-2 hour testing session conducted by a neuropsychologist or psychologist. The Battery consists of measures of intelligence, processing speed, attention, memory, language preference, behavioral/social/emotional function, executive function, adaptive function, and quality of life.
Observational (neuropsychological and behavioral tests)	Cognitive Assessment	Parent and child participants complete the COG Standard Neuropsychological and Behavioral Battery at approximately 9, 30, and 60 months post-diagnosis in a 1-2 hour testing session conducted by a neuropsychologist or psychologist. The Battery consists of measures of intelligence, processing speed, attention, memory, language preference, behavioral/social/emotional function, executive function, adaptive function, and quality of life.

Primary Outcome Measures

Name	Time	Method
Compliance rate for completion of neuropsychological and behavioral battery	Up to 72 months post-diagnosis

Trial Locations

Locations (184)

University of Illinois; 🇺🇸 Chicago, Illinois, United States

Blank Children's Hospital; 🇺🇸 Des Moines, Iowa, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center; 🇺🇸 Houston, Texas, United States

Riley Hospital for Children; 🇺🇸 Indianapolis, Indiana, United States

Saint Vincent Hospital and Health Care Center; 🇺🇸 Indianapolis, Indiana, United States

University of Minnesota/Masonic Cancer Center; 🇺🇸 Minneapolis, Minnesota, United States

Duke University Medical Center; 🇺🇸 Durham, North Carolina, United States

Vanderbilt University/Ingram Cancer Center; 🇺🇸 Nashville, Tennessee, United States

Perth Children's Hospital; 🇦🇺 Perth, Western Australia, Australia

Children's Hospitals and Clinics of Minnesota - Minneapolis; 🇺🇸 Minneapolis, Minnesota, United States

Saint Barnabas Medical Center; 🇺🇸 Livingston, New Jersey, United States

Princess Margaret Hospital for Children; 🇦🇺 Perth, Western Australia, Australia

Nationwide Children's Hospital; 🇺🇸 Columbus, Ohio, United States

Phoenix Childrens Hospital; 🇺🇸 Phoenix, Arizona, United States

University of Alabama at Birmingham Cancer Center; 🇺🇸 Birmingham, Alabama, United States

Legacy Emanuel Children's Hospital; 🇺🇸 Portland, Oregon, United States

University of Nebraska Medical Center; 🇺🇸 Omaha, Nebraska, United States

Children's Hospital of Alabama; 🇺🇸 Birmingham, Alabama, United States

Cedars Sinai Medical Center; 🇺🇸 Los Angeles, California, United States

Valley Children's Hospital; 🇺🇸 Madera, California, United States

Children's Hospital and Research Center at Oakland; 🇺🇸 Oakland, California, United States

Lucile Packard Children's Hospital Stanford University; 🇺🇸 Palo Alto, California, United States

Children's Hospital Colorado; 🇺🇸 Aurora, Colorado, United States

Connecticut Children's Medical Center; 🇺🇸 Hartford, Connecticut, United States

Broward Health Medical Center; 🇺🇸 Fort Lauderdale, Florida, United States

Nicklaus Children's Hospital; 🇺🇸 Miami, Florida, United States

Newark Beth Israel Medical Center; 🇺🇸 Newark, New Jersey, United States

Bronson Methodist Hospital; 🇺🇸 Kalamazoo, Michigan, United States

Prisma Health Richland Hospital; 🇺🇸 Columbia, South Carolina, United States

Floating Hospital for Children at Tufts Medical Center; 🇺🇸 Boston, Massachusetts, United States

University of Iowa/Holden Comprehensive Cancer Center; 🇺🇸 Iowa City, Iowa, United States

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States

Washington University School of Medicine; 🇺🇸 Saint Louis, Missouri, United States

Summerlin Hospital Medical Center; 🇺🇸 Las Vegas, Nevada, United States

University Medical Center of Southern Nevada; 🇺🇸 Las Vegas, Nevada, United States

Sunrise Hospital and Medical Center; 🇺🇸 Las Vegas, Nevada, United States

Dartmouth Hitchcock Medical Center; 🇺🇸 Lebanon, New Hampshire, United States

Hackensack University Medical Center; 🇺🇸 Hackensack, New Jersey, United States

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital; 🇺🇸 New Brunswick, New Jersey, United States

Overlook Hospital; 🇺🇸 Summit, New Jersey, United States

Saint Joseph's Regional Medical Center; 🇺🇸 Paterson, New Jersey, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone; 🇺🇸 New York, New York, United States

Novant Health Presbyterian Medical Center; 🇺🇸 Charlotte, North Carolina, United States

Carolinas Medical Center/Levine Cancer Institute; 🇺🇸 Charlotte, North Carolina, United States

Sanford Broadway Medical Center; 🇺🇸 Fargo, North Dakota, United States

The Toledo Hospital/Toledo Children's Hospital; 🇺🇸 Toledo, Ohio, United States

University of Oklahoma Health Sciences Center; 🇺🇸 Oklahoma City, Oklahoma, United States

Oregon Health and Science University; 🇺🇸 Portland, Oregon, United States

Children's Hospital of Philadelphia; 🇺🇸 Philadelphia, Pennsylvania, United States

Children's Hospital of Pittsburgh of UPMC; 🇺🇸 Pittsburgh, Pennsylvania, United States

M D Anderson Cancer Center; 🇺🇸 Houston, Texas, United States

Children's Hospital of San Antonio; 🇺🇸 San Antonio, Texas, United States

The Children's Hospital at Westmead; 🇦🇺 Westmead, New South Wales, Australia

Royal Children's Hospital; 🇦🇺 Parkville, Victoria, Australia

Children's Hospital of Eastern Ontario; 🇨🇦 Ottawa, Ontario, Canada

Starship Children's Hospital; 🇳🇿 Grafton, Auckland, New Zealand

UT Southwestern/Simmons Cancer Center-Dallas; 🇺🇸 Dallas, Texas, United States

Children's Hospital Los Angeles; 🇺🇸 Los Angeles, California, United States

Rady Children's Hospital - San Diego; 🇺🇸 San Diego, California, United States

Children's Hospital of Orange County; 🇺🇸 Orange, California, United States

UCSF Medical Center-Parnassus; 🇺🇸 San Francisco, California, United States

UCSF Medical Center-Mission Bay; 🇺🇸 San Francisco, California, United States

Children's Healthcare of Atlanta - Egleston; 🇺🇸 Atlanta, Georgia, United States

Advocate Lutheran General Hospital; 🇺🇸 Park Ridge, Illinois, United States

Lehigh Valley Hospital - Muhlenberg; 🇺🇸 Bethlehem, Pennsylvania, United States

Penn State Children's Hospital; 🇺🇸 Hershey, Pennsylvania, United States

Children's Hospital Medical Center of Akron; 🇺🇸 Akron, Ohio, United States

Rainbow Babies and Childrens Hospital; 🇺🇸 Cleveland, Ohio, United States

Cincinnati Children's Hospital Medical Center; 🇺🇸 Cincinnati, Ohio, United States

Saint Christopher's Hospital for Children; 🇺🇸 Philadelphia, Pennsylvania, United States

University of Vermont and State Agricultural College; 🇺🇸 Burlington, Vermont, United States

C S Mott Children's Hospital; 🇺🇸 Ann Arbor, Michigan, United States

Norton Children's Hospital; 🇺🇸 Louisville, Kentucky, United States

AdventHealth Orlando; 🇺🇸 Orlando, Florida, United States

Arnold Palmer Hospital for Children; 🇺🇸 Orlando, Florida, United States

Nemours Children's Clinic - Orlando; 🇺🇸 Orlando, Florida, United States

Wake Forest University Health Sciences; 🇺🇸 Winston-Salem, North Carolina, United States

Kaiser Permanente Downey Medical Center; 🇺🇸 Downey, California, United States

Miller Children's and Women's Hospital Long Beach; 🇺🇸 Long Beach, California, United States

Mattel Children's Hospital UCLA; 🇺🇸 Los Angeles, California, United States

Kaiser Permanente-Oakland; 🇺🇸 Oakland, California, United States

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center; 🇺🇸 Torrance, California, United States

Lee Memorial Health System; 🇺🇸 Fort Myers, Florida, United States

Golisano Children's Hospital of Southwest Florida; 🇺🇸 Fort Myers, Florida, United States

Memorial Regional Hospital/Joe DiMaggio Children's Hospital; 🇺🇸 Hollywood, Florida, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center; 🇺🇸 Miami, Florida, United States

Nemours Children's Clinic-Jacksonville; 🇺🇸 Jacksonville, Florida, United States

Nemours Children's Hospital; 🇺🇸 Orlando, Florida, United States

Johns Hopkins All Children's Hospital; 🇺🇸 Saint Petersburg, Florida, United States

Nemours Children's Clinic - Pensacola; 🇺🇸 Pensacola, Florida, United States

UF Cancer Center at Orlando Health; 🇺🇸 Orlando, Florida, United States

Saint Joseph's Hospital/Children's Hospital-Tampa; 🇺🇸 Tampa, Florida, United States

Saint Mary's Hospital; 🇺🇸 West Palm Beach, Florida, United States

Memorial Health University Medical Center; 🇺🇸 Savannah, Georgia, United States

Tampa General Hospital; 🇺🇸 Tampa, Florida, United States

University of Chicago Comprehensive Cancer Center; 🇺🇸 Chicago, Illinois, United States

Lurie Children's Hospital-Chicago; 🇺🇸 Chicago, Illinois, United States

Advocate Children's Hospital-Oak Lawn; 🇺🇸 Oak Lawn, Illinois, United States

Loyola University Medical Center; 🇺🇸 Maywood, Illinois, United States

Advocate Children's Hospital-Park Ridge; 🇺🇸 Park Ridge, Illinois, United States

Saint Jude Midwest Affiliate; 🇺🇸 Peoria, Illinois, United States

Johns Hopkins University/Sidney Kimmel Cancer Center; 🇺🇸 Baltimore, Maryland, United States

University of Maryland/Greenebaum Cancer Center; 🇺🇸 Baltimore, Maryland, United States

Wayne State University/Karmanos Cancer Institute; 🇺🇸 Detroit, Michigan, United States

University of Mississippi Medical Center; 🇺🇸 Jackson, Mississippi, United States

Mercy Hospital Saint Louis; 🇺🇸 Saint Louis, Missouri, United States

Alliance for Childhood Diseases/Cure 4 the Kids Foundation; 🇺🇸 Las Vegas, Nevada, United States

Albany Medical Center; 🇺🇸 Albany, New York, United States

The Steven and Alexandra Cohen Children's Medical Center of New York; 🇺🇸 New Hyde Park, New York, United States

Roswell Park Cancer Institute; 🇺🇸 Buffalo, New York, United States

Mount Sinai Hospital; 🇺🇸 New York, New York, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center; 🇺🇸 New York, New York, United States

Memorial Sloan Kettering Cancer Center; 🇺🇸 New York, New York, United States

New York Medical College; 🇺🇸 Valhalla, New York, United States

State University of New York Upstate Medical University; 🇺🇸 Syracuse, New York, United States

Mission Hospital; 🇺🇸 Asheville, North Carolina, United States

Cleveland Clinic Foundation; 🇺🇸 Cleveland, Ohio, United States

Sanford USD Medical Center - Sioux Falls; 🇺🇸 Sioux Falls, South Dakota, United States

Driscoll Children's Hospital; 🇺🇸 Corpus Christi, Texas, United States

Medical City Dallas Hospital; 🇺🇸 Dallas, Texas, United States

Cook Children's Medical Center; 🇺🇸 Fort Worth, Texas, United States

Covenant Children's Hospital; 🇺🇸 Lubbock, Texas, United States

University of Texas Health Science Center at San Antonio; 🇺🇸 San Antonio, Texas, United States

Methodist Children's Hospital of South Texas; 🇺🇸 San Antonio, Texas, United States

University of Virginia Cancer Center; 🇺🇸 Charlottesville, Virginia, United States

Children's Hospital of The King's Daughters; 🇺🇸 Norfolk, Virginia, United States

Carilion Clinic Children's Hospital; 🇺🇸 Roanoke, Virginia, United States

Seattle Children's Hospital; 🇺🇸 Seattle, Washington, United States

Providence Sacred Heart Medical Center and Children's Hospital; 🇺🇸 Spokane, Washington, United States

West Virginia University Charleston Division; 🇺🇸 Charleston, West Virginia, United States

Saint Vincent Hospital Cancer Center Green Bay; 🇺🇸 Green Bay, Wisconsin, United States

Marshfield Medical Center-Marshfield; 🇺🇸 Marshfield, Wisconsin, United States

Children's Hospital of Wisconsin; 🇺🇸 Milwaukee, Wisconsin, United States

Royal Children's Hospital-Brisbane; 🇦🇺 Herston, Queensland, Australia

John Hunter Children's Hospital; 🇦🇺 Hunter Regional Mail Centre, New South Wales, Australia

Sydney Children's Hospital; 🇦🇺 Randwick, New South Wales, Australia

Queensland Children's Hospital; 🇦🇺 South Brisbane, Queensland, Australia

Women's and Children's Hospital-Adelaide; 🇦🇺 North Adelaide, South Australia, Australia

Alberta Children's Hospital; 🇨🇦 Calgary, Alberta, Canada

British Columbia Children's Hospital; 🇨🇦 Vancouver, British Columbia, Canada

CancerCare Manitoba; 🇨🇦 Winnipeg, Manitoba, Canada

McMaster Children's Hospital at Hamilton Health Sciences; 🇨🇦 Hamilton, Ontario, Canada

IWK Health Centre; 🇨🇦 Halifax, Nova Scotia, Canada

Hospital for Sick Children; 🇨🇦 Toronto, Ontario, Canada

Centre Hospitalier Universitaire Sainte-Justine; 🇨🇦 Montreal, Quebec, Canada

Saskatoon Cancer Centre; 🇨🇦 Saskatoon, Saskatchewan, Canada

Christchurch Hospital; 🇳🇿 Christchurch, New Zealand

University Pediatric Hospital; 🇵🇷 San Juan, Puerto Rico

Yale University; 🇺🇸 New Haven, Connecticut, United States

Kalamazoo Center for Medical Studies; 🇺🇸 Kalamazoo, Michigan, United States

Children's Mercy Hospitals and Clinics; 🇺🇸 Kansas City, Missouri, United States

UNC Lineberger Comprehensive Cancer Center; 🇺🇸 Chapel Hill, North Carolina, United States

Children's National Medical Center; 🇺🇸 Washington, District of Columbia, United States

Massachusetts General Hospital Cancer Center; 🇺🇸 Boston, Massachusetts, United States

Dana-Farber Cancer Institute; 🇺🇸 Boston, Massachusetts, United States

Saint Luke's Mountain States Tumor Institute; 🇺🇸 Boise, Idaho, United States

Helen DeVos Children's Hospital at Spectrum Health; 🇺🇸 Grand Rapids, Michigan, United States

Michigan State University Clinical Center; 🇺🇸 East Lansing, Michigan, United States

Primary Children's Hospital; 🇺🇸 Salt Lake City, Utah, United States

St. Jude Children's Research Hospital; 🇺🇸 Memphis, Tennessee, United States

Cardon Children's Medical Center; 🇺🇸 Mesa, Arizona, United States

BI-LO Charities Children's Cancer Center; 🇺🇸 Greenville, South Carolina, United States

Greenville Cancer Treatment Center; 🇺🇸 Greenville, South Carolina, United States

Alfred I duPont Hospital for Children; 🇺🇸 Wilmington, Delaware, United States

Ascension Saint John Hospital; 🇺🇸 Detroit, Michigan, United States

T C Thompson Children's Hospital; 🇺🇸 Chattanooga, Tennessee, United States

Morristown Medical Center; 🇺🇸 Morristown, New Jersey, United States

MedStar Georgetown University Hospital; 🇺🇸 Washington, District of Columbia, United States

West Virginia University Healthcare; 🇺🇸 Morgantown, West Virginia, United States

East Tennessee Childrens Hospital; 🇺🇸 Knoxville, Tennessee, United States

Children's Hospital New Orleans; 🇺🇸 New Orleans, Louisiana, United States

Ochsner Medical Center Jefferson; 🇺🇸 New Orleans, Louisiana, United States

Dell Children's Medical Center of Central Texas; 🇺🇸 Austin, Texas, United States

Virginia Commonwealth University/Massey Cancer Center; 🇺🇸 Richmond, Virginia, United States

University of Florida Health Science Center - Gainesville; 🇺🇸 Gainesville, Florida, United States

University of Hawaii Cancer Center; 🇺🇸 Honolulu, Hawaii, United States

Kapiolani Medical Center for Women and Children; 🇺🇸 Honolulu, Hawaii, United States

Montefiore Medical Center - Moses Campus; 🇺🇸 Bronx, New York, United States

University of Kentucky/Markey Cancer Center; 🇺🇸 Lexington, Kentucky, United States

University of Wisconsin Hospital and Clinics; 🇺🇸 Madison, Wisconsin, United States

University of New Mexico Cancer Center; 🇺🇸 Albuquerque, New Mexico, United States

University of Rochester; 🇺🇸 Rochester, New York, United States

Dayton Children's Hospital; 🇺🇸 Dayton, Ohio, United States

Rhode Island Hospital; 🇺🇸 Providence, Rhode Island, United States