Effectiveness of Different Intensities Walking Exercise in Improving Depression in Older Adults With Major Depressive Disorder, A Pilot Randomized Controlled Trial

The University of Hong Kong1 site in 1 country35 target enrollmentNovember 1, 2019

ConditionsMajor Depressive Disorder (MDD)

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Major Depressive Disorder (MDD)
Sponsor: The University of Hong Kong
Enrollment: 35
Locations: 1
Primary Endpoint: Depressive symptoms-Beck Depression Inventory (BDI)
Status: Completed
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This pilot randomized controlled trial aims at investigating the effects of different intensities of aerobic walking exercise to alleviate depression in older adults with major depressive disorder. Both baseline and post-intervention measurements will be conducted at the Exercise Physiology Laboratory, Division of Kinesiology, School of Public Health, The University of Hong Kong, while the exercise intervention will be conducted outdoors in a small group setting (3-5 participants).
Three-time-per-week moderate-intensity (~3.5 METs) or vigorous-intensity (~7 METs) walking exercise will be prescribed to participants in two exercise groups, while the participants in the waitlist group will receive no intervention. The intervention duration is 12 weeks.
We will recruit participants from the community in HK. Interested participants will be invited for a semi-structured interview including an assessment on the Beck Depression Inventory and medical history record to confirm eligibility.

Registry

clinicaltrials.gov

Start Date

November 1, 2019

End Date

December 31, 2020

Last Updated

4 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

The University of Hong Kong

Responsible Party

Principal Investigator

Parco M. Siu, PhD

Associate Professor & Head of Division of Kinesiology

The University of Hong Kong

Eligibility Criteria

Inclusion Criteria

•Older adults aged equal or over 50 years;
•Ethnic Chinese;
•Beck Depression Inventory score over 9 points;
•Diagnosed with MDD and currently on pharmacological treatment for MDD.

Exclusion Criteria

•Incapable of participating in physical exercise with major confounding conditions which are known to affect mobility;
•Cannot walk without assistive device;
•Regular exercise habit (defined as exercise \> 3 times per week and each time \> 50 minutes)
•Any serious somatic condition that prevents walking exercise participation (such as limb loss)
•History of major diseases e.g. cancer, cardio-/cerebrovascular, neurodegenerative and renal diseases;
•Diagnosis of dementia/Alzheimer's disease, or currently using antidementia medication;

Outcomes

Primary Outcomes

Depressive symptoms-Beck Depression Inventory (BDI)

Time Frame: 3 Months

BDI is a 21-item self-reporting questionnaire for evaluation of the severity of depression in both normal and psychiatric populations. Each item includes four statements numbered from 0 to 3, with a higher number indicating more severe depressive symptoms. Participants will be asked to circle the statement that can best describe them in a paper-pencil based manner. The BDI score interpretation is: less than 10: no or minimal depression, 10-18: mild-to-moderate depression, 19-29: moderate-to-severe depression, over 30: severe depression

Secondary Outcomes

Antidepressants Usage-Medication History(3 Months)
Anxiety-Generalized Anxiety Disorder 7-item (GAD-7) scale(3 Months)
Sleep quality-Pittsburgh Sleep Quality Index (PSQI)(3 Months)
Quality of life-12-item short form health survey (SF-12)(3 Months)
Cardiorespiratory fitness-VO2max Test(3 Months)
Resting heart rate(3 Months)
Body Mass Index(3 Months)
Daily physical activity-International Physical Activity Questionnaire (IPAQ)(3 Months)