Comparison of two regimens of total intravenous anaesthesia for time to recovery from anaesthesia.

Not yet recruiting

• Registration Number: CTRI/2021/02/030967
• Lead Sponsor: LADY HARDINGE MEDICAL COLLEGE

Brief Summary

Total Intravenous Anaesthesia (TIVA) is a technique of general anaesthesia which uses a combination of agents given exclusively by the intravenous route without the use of inhalation agents. Till recently, inhalational anaesthetic agents have remained the routine choice for maintenance of anaesthesia, but they have their own drawbacks and shortcomings such as cost, different specific vaporizers which require repeated maintenance and scavenging system to prevent pollution of operation room.1 However, in terms of global warming potential, inhalational anaesthetic agents still remain a big hazard for the environment.2 Apart from avoiding these, TIVA decreases post-operative nausea and vomiting (PONV), lessens neurohumoral response, avoids distension of air-filled spaces and postoperative diffusion hypoxemia.1

Opioids are very commonly used in modern methods of anaesthesia. The use of opioids is based on their ability to provide analgesia during the peri operative period.3 Opioids used as the part of a balanced anaesthesia are known to have a lot of side effects such as sedation, respiratory depression, post-operative nausea and vomiting, urinary retention, constipation and opioid induced hyperalgesia.4 These side effects can delay post-operative recovery and early mobilization of the patient. Apart from this opioid are also known for their physical dependence.

Opioid free total intravenous anaesthesia provides a viable alternative for these problems.

The principle of opioid free anaesthesia is to gain analgesic effects from different drugs while minimizing side effects particularly those of opioids,5 with added advantages of decreased postoperative nausea and vomiting and analgesic requirement post operatively.

Ketamine, an NMDA antagonist and dexmedetomidine, an alpha 2 adrenoreceptor agonist have been used in lieu of opioids to provide analgesia intraoperatively. Their use has strengthened the role of opioid free TIVA for maintenance of anaesthesia.

This study is being planned to compare the postoperative recovery profile of patients receiving opioid free TIVA with either ketamine or dexmedetomidine.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-02-02
• Study Start: 2021-04-02

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1.ASA I and ASA II 2.Undergoing elective surgery of duration 1-4 hours.

Exclusion Criteria

• 1.Any known allergy to drugs used in the study.
• 2.Known psychiatric illness.
• 3.Narrow angle glaucoma.
• 4.Addiction to drugs and alcohol.
• 5.Chronic opioid therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time taken to achieve Modified Aldrete Score of ≥9 (Mean±SD) using propofol with ketamine or dexmedetomidine	postoperative every minute till Modified Adrette Score is more than or equal to 9

Secondary Outcome Measures

Name	Time	Method
1.haemodynamic complications (bradycardia, tachycardia, hypotension, hypertension)	2.Mean Bi-spectral index

Trial Locations

Locations (1)

LADY HARDINGE MEDICAL COLLEGE; 🇮🇳 Central, DELHI, India

LADY HARDINGE MEDICAL COLLEGE

🇮🇳Central, DELHI, India

DR NISHANT KUMAR

Principal investigator

9811934659

kumarnishant@yahoo.co.uk