Prediabetes, Exercise, and Appetite Regulation
- Conditions
- Appetitive BehaviorPreDiabetes
- Interventions
- Behavioral: Resistance Exercise
- Registration Number
- NCT04910763
- Lead Sponsor
- University of Utah
- Brief Summary
The purpose of the study is to learn about how type of exercise influences measures of appetite regulation.
- Detailed Description
The primary objective of this study is to understand the relationship between exercise modality and appetite regulation in a population with pre-diabetes. The study includes a screening visit to ensure eligibility of participants, baseline assessments, a resistance exercise intervention, and post intervention measurements. The variables of interest include, but are not limited to, hormonal responses to exercise training pertaining to appetite, food cravings, appetite ratings. activity levels, body composition, and ten repetition-max strength. The aim of this study is to better understand the mechanisms involved in the correlation or causation of any improvements in fitness and appetite regulation in a cohort with pre-diabetes.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 23
- Age 18-50 years of age
- BMI between 27-40 kg/m²
- Hemoglobin A1c level between 5.7% and 6.4%
- Physical Activity (less than 150 min/week moderate-intensity Physical Activity, no more than 1 session/week of resistance exercise)
- Unstable Cardiovascular Disease
- Uncontrolled hypertension
- Severe hypertriglyceridemia
- History of or active liver disease
- Uncontrolled thyroid disease
- Active cancer diagnosis
- Smoking
- Engaged in exercise or diet program
- History of bariatric surgery
- GI malabsorptive disorders
- Significant diet intolerances
- History of major psychiatric disorder
- presence of alcohol or substance abuse;
- medications affecting weight,
- EI or EE in past 6 months;
- women currently pregnant, lactating, less than 6 months post-partum, or postmenopausal.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Resistance Exercise Resistance Exercise Resistance exercise will be training all major muscle groups 2x/week (2 days upper body, 2 days lower body) at 40-50% 1 repetition max (RM; estimated from 10 RM baseline testing) for 3 sets of 10-12 reps. This equals 4x/week for the 3 week intervention period.
- Primary Outcome Measures
Name Time Method Changes in Appetite Rating Baseline: Pre-Meal , 30 minutes, 60 minutes, 90 minutes, and 120 minutes post meal / Post-intervention(Week 4) :Pre-Meal, 30 minutes, 60 minutes, 90 minutes ,and 120 minutes post meal Hunger/Satiety before/after consumption of a meal
Changes in Hormonal Response to Feeding Baseline: Pre-Meal , 30 minutes, 60 minutes, 90 minutes, and 120 minutes post meal / Post-intervention(Week 4) :Pre-Meal, 30 minutes, 60 minutes, 90 minutes ,and 120 minutes post meal Assessment of Ghrelin levels analyzed in blood samples before/after feeding.
- Secondary Outcome Measures
Name Time Method Changes in Maximal Strength Baseline and Post-intervention(Week 4) Measurement via 10 repetition-max testing.
Changes in Physical Activity Levels Baseline and Post-intervention(Week 4) Measured via ActivPal Monitor
Change in Ad libitum Energy Intake - In lab Baseline and Post-intervention(Week 4) In lab ad libitum buffet lunch (via weigh and measure methodology)
Changes in Food-Related Behaviors Baseline and Post-intervention(Week 4) Evaluated via the Weight Efficacy Lifestyle Questionnaire
Changes in Body Composition Baseline and Post-intervention(Week 4) Measured via BodPod
Changes in Ad libitum Energy Intake - Free Living Baseline and Post-intervention(Week 4) 3 days of free-living ad libitum energy intake (via self-report)
Trial Locations
- Locations (1)
University of Utah
🇺🇸Salt Lake City, Utah, United States