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临床试验/NCT02272205
NCT02272205已完成不适用

Evaluation of the Effect of a Conventional Antibiotic Prophylaxis on the Positivity of Intraoperative Bacteriological Samples During a Change of Hip or Knee Infected at a Time

University Hospital, Strasbourg, France0 个研究点目标入组 80 人开始时间: 2014年11月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
80
主要终点
concordance of pre-and intraoperative bacteriological documentation

研究概览

简要总结

Infection is a serious complications after undergoing total hip replacement. It occurs in about 1% of cases. The optimal treatment of these infections is discussed. The team validated by international publications change strategy of the infected prosthesis at a time.

Antibiotic prophylaxis has significantly reduced the infection intraoperative contamination in orthopedic surgery rates. It must be conventionally administered before the surgical incision. In response to infection, it is typically recommended to start this antibiotic after the completion of the deep bacteriological samples, so as not to negate the risk of these samples by the prior administration of antibiotics. This attitude, however, is not formally validated by the scientific literature. In contrast, two recent publications challenge this practice, and suggest the use of a conventional antibiotic prophylaxis even in septic interventions. Our multidisciplinary team opted for a few months for this new strategy. We wish to evaluate the influence of this new approach results in the treatment of infection in total hip or knee.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.

排除标准

  • patients operated in service before January 2012 and after July 2013 for treatment of an infection of total hip or knee.

结局指标

主要结局

concordance of pre-and intraoperative bacteriological documentation

时间窗: preoperative; intraoperative

concordance of pre-and intraoperative bacteriological documentation (division into 3 classes: complete, partial, no - Chi-square test

次要结局

  • rates to relapse of the initial infection or a new infection(preoperative; intraoperative)

研究者

发起方
University Hospital, Strasbourg, France
申办方类型
Other
责任方
Sponsor

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