Evaluation of Conventional Antibiotic Prophylaxis During a Change of Hip or Knee Infected at a Time

• Conditions: Total Hip Replacement

• Registration Number: NCT02272205
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Infection is a serious complications after undergoing total hip replacement. It occurs in about 1% of cases. The optimal treatment of these infections is discussed. The team validated by international publications change strategy of the infected prosthesis at a time.

Antibiotic prophylaxis has significantly reduced the infection intraoperative contamination in orthopedic surgery rates. It must be conventionally administered before the surgical incision. In response to infection, it is typically recommended to start this antibiotic after the completion of the deep bacteriological samples, so as not to negate the risk of these samples by the prior administration of antibiotics. This attitude, however, is not formally validated by the scientific literature. In contrast, two recent publications challenge this practice, and suggest the use of a conventional antibiotic prophylaxis even in septic interventions. Our multidisciplinary team opted for a few months for this new strategy. We wish to evaluate the influence of this new approach results in the treatment of infection in total hip or knee.

Detailed Description

Not available

Study Timeline

• Status Verified: 2014-10
• Study First Submitted: 2014-10-20
• Study First Submitted QC: 2014-10-20
• Last Update Submitted: 2014-10-20
• Study First Posted: 2014-10-22
• Last Update Posted: 2014-10-22
• Study Start: 2014-11
• Primary Completion: 2015-10
• Study Completion: 2015-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.

Exclusion Criteria

• patients operated in service before January 2012 and after July 2013 for treatment of an infection of total hip or knee.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
concordance of pre-and intraoperative bacteriological documentation	preoperative; intraoperative	concordance of pre-and intraoperative bacteriological documentation (division into 3 classes: complete, partial, no - Chi-square test

Secondary Outcome Measures

Name	Time	Method
rates to relapse of the initial infection or a new infection	preoperative; intraoperative	rates to relapse of the initial infection or a new infection (survival curves according to Kaplan-Meier with log-rank test)