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Clinical Trials/NCT02272205
NCT02272205
Completed
N/A

Evaluation of the Effect of a Conventional Antibiotic Prophylaxis on the Positivity of Intraoperative Bacteriological Samples During a Change of Hip or Knee Infected at a Time

University Hospital, Strasbourg, France0 sites80 target enrollmentNovember 1, 2014

Overview

Phase
N/A
Intervention
Not specified
Conditions
Total Hip Replacement
Sponsor
University Hospital, Strasbourg, France
Enrollment
80
Primary Endpoint
concordance of pre-and intraoperative bacteriological documentation
Status
Completed
Last Updated
7 months ago

Overview

Brief Summary

Infection is a serious complications after undergoing total hip replacement. It occurs in about 1% of cases. The optimal treatment of these infections is discussed. The team validated by international publications change strategy of the infected prosthesis at a time.

Antibiotic prophylaxis has significantly reduced the infection intraoperative contamination in orthopedic surgery rates. It must be conventionally administered before the surgical incision. In response to infection, it is typically recommended to start this antibiotic after the completion of the deep bacteriological samples, so as not to negate the risk of these samples by the prior administration of antibiotics. This attitude, however, is not formally validated by the scientific literature. In contrast, two recent publications challenge this practice, and suggest the use of a conventional antibiotic prophylaxis even in septic interventions. Our multidisciplinary team opted for a few months for this new strategy. We wish to evaluate the influence of this new approach results in the treatment of infection in total hip or knee.

Registry
clinicaltrials.gov
Start Date
November 1, 2014
End Date
October 31, 2017
Last Updated
7 months ago
Study Type
Observational
Sex
All

Investigators

Sponsor
University Hospital, Strasbourg, France
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.

Exclusion Criteria

  • patients operated in service before January 2012 and after July 2013 for treatment of an infection of total hip or knee.

Outcomes

Primary Outcomes

concordance of pre-and intraoperative bacteriological documentation

Time Frame: preoperative; intraoperative

concordance of pre-and intraoperative bacteriological documentation (division into 3 classes: complete, partial, no - Chi-square test

Secondary Outcomes

  • rates to relapse of the initial infection or a new infection(preoperative; intraoperative)

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