Cognitive enhancement: an investigation of non-invasive electrical brain stimulation methods.

Not Applicable

Completed

• Conditions: Major Depression; Mental Health - Depression; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12612001061820
• Lead Sponsor: Dr Rebecca Segrave

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-10-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Major Depression
1. Able to provide informed consent
2. Meet criteria for a major depressive episode as determined by structured clinical interview.

Healthy Controls
1. Able to provide informed consent
2. Have no history of mental illness as determined by self report and structured clinical interview

Exclusion Criteria

Major Depression
1. Comorbid psychotic illness

All Participants
1. Unstable medical condition, neurological disorder or are currently pregnant or lactating
2. Metal in the cranium, a pacemaker, cochlear implant medication pump or other implanted electronic device

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Stimulation will be delivered concurrent with a mathematical task and the primary outcome measure will be a between groups comparison of task proficiency.[During application of active/sham stimulation]

Secondary Outcome Measures

Name	Time	Method
Resting EEG activity[Pre and post application of active/sham stimulation];EEG activity during completion of a working memory task[Pre and post application of active/sham stimulation];DLPFC cortical inhibition measured via TMS/EEG[Pre and post application of active/sham stimulation];Performance on a verbal working-memory task[Pre and post application of active/sham stimulation]