Identifying the differences in the blood chemistry, electrical and structural properties of the heart between participants with and without prior strokes.

Not Applicable

Recruiting

• Conditions: Stroke; Heart Disease; Stroke - Ischaemic; Atrial Fibrillation; Thromboembolism; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12617000771358
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-05-26
• Last Update Posted: 27 April 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Stroke group: Admission diagnosis of ischaemic stroke or TIA, older than 55 years of age
Control group: Age matched patients without prior history of stroke or TIA

Exclusion Criteria

1.Unable to provide informed consent
2.Pregnancy
3.Chronic kidney disease; stage 4 or greater
4.Patients with significant ventricular arrhythmias on extended monitoring

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary Outcome : Difference between stroke and control groups in echocardiographic parameters as a composite of left atrial volumetric function, left atrial size and left atrial strain. <br>[Stroke group to undergo an echocardiogram within 3 months of the index stroke<br>];Primary Outcome : Difference between stroke and control groups with regards to blood markers of inflammation, thrombogenesis and endothelial function. <br><br>Composite of IL-6, hsCRP, Thormbin/Antithrombin complex, D-Dimer, ADMA, Von Willebrand Factor, Pro-ntBNP, hsTroponin, <br><br>[The biomarkers will be collected from stroke patients within 3 months of index stroke.];Primary Outcome : Difference between stroke and control groups in electrical substrate <br><br>[Stroke patients will undergo electrophysiologic testing within 6 months of index event.<br>Control group will be assessed during routine indicated electrophysiologic studies. ]

Secondary Outcome Measures

Name	Time	Method
Compare ectopic burden between stroke and control groups as assessed by total number of premature atrial complexes in 24 hours of Holter monitoring.[Single point measure within 3 months of stroke. <br>Control group will be recruited during routine indicated 24 hour monitoring.]