Differences in blood metabolic and molecular biomarkers among normal weight, mildly obese, and moderately obese subjects

Completed

• Conditions: Blood biomarkers of people classified as normal weight, mildly obese and moderately obese according to body mass index (BMI) calculation.; Nutritional, Metabolic, Endocrine; Obesity

• Registration Number: ISRCTN16654407
• Lead Sponsor: Kyungpook National University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-05-07
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 37

Inclusion Criteria

1. Participants classed as obese, having a BMI of 25~30 kg/m2 and a normal medical history
2. Healthy participants having a BMI 18.5~23 kg/m2

Exclusion Criteria

1. History of cancer or cardiac, renal, hepatic, or infectious disease.
2. Current treatment with insulin
3. Current use of drugs for controlling blood glucose, blood lipids and body weight.
4. History of gastrointestinal surgery
5. Consumption of functional foods or medications that may affect the results of this study

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Leptin, lipids (LDL- and HDL-cholesterol), apolipoprotein B levels and adiponectin<br>2. Circulating levels of inflammatory cytokines and markers of insulin resistance, oxidative stress, and liver damage.

Secondary Outcome Measures

Name	Time	Method
1. PBMC transcriptome data<br>2. Signaling pathways: oxidative phosphorylation; triglyceride synthesis; carbohydrate metabolism; insulin, mTOR, FOXO, RAP1, RAS, and TGF-ß signaling; and ECM–receptor interaction.