Anaesthesiological Routine Care for Thrombectomy in Cerebral Ischaemia

Recruiting

• Conditions: Cerebral Ischemia

• Registration Number: NCT04522856
• Lead Sponsor: European Society of Anaesthesiology

Brief Summary

Endovascular thrombectomy is the standard of care for acute ischaemic stroke due to large-vessel occlusion. Current guidelines for periprocedural anaesthesiological care give gross recommendations on management of stroke patients during recanalization, but lack detailed information.

To determine how anaesthesiologists support endovascular thrombectomy with regard to anaesthetic technique, choice of substances, haemodynamic management, and ventilation. With a multivariate analysis, the investigators will look for the factors of anesthetic management that are independently correlated with a good or bad outcome.

Detailed Description

see brief summary

Study Timeline

• Study First Submitted: 2020-06-15
• Study First Submitted QC: 2020-08-18
• Study First Posted: 2020-08-21
• Study Start: 2021-08-01
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-16
• Last Update Posted: 2024-04-17
• Primary Completion: 2024-04-30
• Study Completion: 2024-08-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2500

Inclusion Criteria

• Endovascular stroke treatment involving anaesthesia care

Exclusion Criteria

• In-hospital onset of stroke
• Inclusion in an interventional study concerning the anaesthesia protocol
• Age under 18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Neurological outcome 90 days after the stroke	90 days	Neurological outcome is measured using the modified Rankin Scale \[0-6\], with higher values indicating worse outcome. As a Primary Outcome Measure, the scale will be dichotomized into good (modified Rankin Scale ≤ 2) versus poor (modified Rankin Scale \> 2) outcome.

Secondary Outcome Measures

Name	Time	Method
Mortality	90 days	Mortality rate 90 days after the stroke. Mortality rate is the percentage of patients that have died within 90 days following their stroke.
Grade of recanalization	sixty minutes	Recanalization is classified according to the modified Thrombolysis in Cerebral Infarction classification (mTICI) \[0 - 3\], with higher values indicating better reperfusion.
Proportion of patients breathing spontaneously	sixty minutes	Proportion of patients breathing spontaneously after thrombectomy \[Time Frame: On transfer from angiography suite after thrombectomy, which typically takes 1 hour\]. This is defined as percentage of patients that breathe spontaneously without laryngeal mask, laryngeal tube, or endotracheal tube after thrombectomy.
Duration	30 Minutes	Duration \[minutes\] from patient's arrival in angiography suite to arterial puncture for endovascular thrombectomy.; Duration \[minutes\] from patient's arrival in angiography suite to arterial puncture for endovascular thrombectomy.; Duration \[minutes\] from arterial puncture to end of endovascular thrombectomy.

Trial Locations

Locations (1)

TU München; 🇩🇪 München, Germany