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Clinical Trials/NCT05629832
NCT05629832
Completed
Not Applicable

Transpulmonary Pressure Guided Mechanical Ventilation Strategy for Right Ventricle Protection in Acute Respiratory Distress Syndrome

Beijing Chao Yang Hospital1 site in 1 country40 target enrollmentJanuary 1, 2023
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ConditionsAcute Respiratory Distress SyndromeAcute Cor Pulmonale
Interventionsmechanical ventilation strategy guided by transpulmonary pressure

Overview

Phase
Not Applicable
Intervention
mechanical ventilation strategy guided by transpulmonary pressure
Conditions
Acute Respiratory Distress Syndrome
Sponsor
Beijing Chao Yang Hospital
Enrollment
40
Locations
1
Primary Endpoint
Pulmonary vascular resistance (PVR)
Status
Completed
Last Updated
last month
OverviewInvestigatorsEligibility CriteriaArms & InterventionsOutcomesSitesSimilar Trials

Overview

Brief Summary

To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.

Registry
clinicaltrials.gov
Start Date
January 1, 2023
End Date
December 31, 2024
Last Updated
last month
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Beijing Chao Yang Hospital
Responsible Party
Principal Investigator
Principal Investigator

Xiao Tang

Doctor

Beijing Chao Yang Hospital

Eligibility Criteria

Inclusion Criteria

  • •duration of invasive mechanical ventilation less than 72 hours;
  • •meet the diagnostic criteria of Berlin definition for ARDS;
  • •age older than 18

Exclusion Criteria

  • •esophageal surgery or damage;
  • •cardiac surgery;
  • •severe bronchopleural fistula;
  • •serious arrhythmia; pneumothorax;
  • •tricuspid stenosis;
  • •heparin allergy;
  • •chronic pulmonary heart disease

Arms & Interventions

PTP group

Intervention: mechanical ventilation strategy guided by transpulmonary pressure

Control group

Outcomes

Primary Outcomes

Pulmonary vascular resistance (PVR)

Time Frame: 3 days

PVR will measured by Swan-Ganz catheter

Pulmonary vascular compliance

Time Frame: 3 days

Pulmonary vascular compliance will be calculated using pulmonary artery pressure divided by stroke output measured by Swan-Ganz catheter.

Study Sites (1)

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