Transpulmonary Pressure in Right Ventricle Protection of ARDS

Not Applicable

Recruiting

• Conditions: Acute Respiratory Distress Syndrome; Acute Cor Pulmonale
• Interventions: Procedure: mechanical ventilation strategy guided by transpulmonary pressure

• Registration Number: NCT05629832
• Lead Sponsor: Beijing Chao Yang Hospital

Brief Summary

To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-11-14
• Study First Submitted QC: 2022-11-18
• Study First Posted: 2022-11-29
• Study Start: 2023-01-01
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-11
• Last Update Posted: 2024-04-12
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• duration of invasive mechanical ventilation less than 72 hours;
• meet the diagnostic criteria of Berlin definition for ARDS;
• age older than 18

Exclusion Criteria

• esophageal surgery or damage;
• cardiac surgery;
• severe bronchopleural fistula;
• serious arrhythmia; pneumothorax;
• tricuspid stenosis;
• heparin allergy;
• chronic pulmonary heart disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
PTP group	mechanical ventilation strategy guided by transpulmonary pressure	-

Primary Outcome Measures

Name	Time	Method
Pulmonary vascular resistance (PVR)	3 days	PVR will measured by Swan-Ganz catheter
Pulmonary vascular compliance	3 days	Pulmonary vascular compliance will be calculated using pulmonary artery pressure divided by stroke output measured by Swan-Ganz catheter.

Trial Locations

Locations (1)

Beijing Chao-Yang Hospital; 🇨🇳 Beijing, Beijing, China