transpulmonary pressure guided ventilation in ARDS

Phase 3

• Conditions: Health Condition 1: J99- Respiratory disorders in diseasesclassified elsewhere

• Registration Number: CTRI/2021/03/032431
• Lead Sponsor: self

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Patients will be included in the study if they have moderate-to-severe ARDS according to the American-European Consensus Conference definitions.

Duration of ARDS 36 hours or less from meeting final Berlin criterion

Age more than 18 years.

Exclusion Criteria

Received mechanical ventilation more than 96â??h.

Recently treated for bleeding varices, stricture, haematemesis, esophageal trauma, recent esophageal surgery or other contraindication for nasogastric tube placement.

History of lung or liver transplantation.

Severe chronic liver disease (Child-Pugh Score >=12).

Patients not committed to full support.

Inability to get informed consent from the patient or surrogate.

Use of rescue therapies prior to enrolment (including nitric oxide, ECMO, prone positioning)

Evidence of active air leak from the lung (including bronchopleural fistula, pneumothorax, pneumomediastinum or air leak from existing chest tube).

Study & Design

• Study Type: Interventional
• Study Design: Not specified