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Transpulmonary pressure at prone positioning in patients with severe acute respiratory distress syndrome

Not Applicable
Recruiting
Conditions
J80.0
Registration Number
DRKS00017449
Lead Sponsor
niversitätsmedizin Mannheim
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Recruiting
Sex
All
Target Recruitment
60
Inclusion Criteria

Moderate to severe ARDS (acute respiratory distress syndrome) (PaO2/FiO2 < 200 mmHg), consent to the study

Exclusion Criteria

- mechanical ventilation for less than 12 hours or more than 5 days
- severe head injury
- inherited cardiac malformations
- severe cardial valvular pathologies
- presence of arrhythmias
- immunosuppression
- end-stage chronic organ failure
- expected survival of less than 24 hours
- pregnancy

Study & Design

Study Type
interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
End-expiratory transpulmonary pressure in prone position when using different methods of PEEP titration. The respiratory mechanics are evaluated at the bedside as soon as the inclusion criteria are met.
Secondary Outcome Measures
NameTimeMethod
ung mechanics, intraabdominal pressure and hemodynamics in prone position when using different methods of PEEP titration. As soon as the inclusion criteria are met, respiratory mechanics, hemodynamic and other physiological parameters are measured.
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