Comparing the Effects of Isoflurane-Sufentanil Anesthesia and Propofol-Sufentanil Anesthesia on Serum Cortisol Levels in Open Heart Surgery
Phase 2
- Conditions
- Cronary Artery Disease Three Vessel Disease.Atherosclerotic heart disease Coronary (artery): atherosclerosis
- Registration Number
- IRCT2015071713456N5
- Lead Sponsor
- Vice Chancellaor for Research of Guilan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
Inclusion Criteria:72 patients 18-65 years old with ASA classII-III who undergo CABGs with cardiopulmonary bypass; All samples will take on the morning between 7:30 am to 8:30 am.
Exclusion Criteria : Emergency surgery; Hepatic or Renal failure; Neurologic Disorders; Diabetes; Malignancies; BMI>38 kg/m2; Steroid therapy before operation; Chronic Drug abuse; Thyroid dysfunction and Redo operation; sever hemorrhage ; arrhythmia resistant to treatment ;time of CPB over than 100 min ; Hct<25%;prolonged intubation in ICU; use of sympathomimetic drug to treat or help IABP and weaning(epinphrine ,norepinephrine)
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood Cortisol Level. Timepoint: Preoperative ,cardiopulmonary Bypass,24 hour after surgery. Method of measurement: the blood cortisol level mcg/litr.
- Secondary Outcome Measures
Name Time Method Mean Arterial Pressure (mmhg). Timepoint: Preoperative,During CPB and After 24 hours). Method of measurement: with monitoring of blood pressure.