The Bern Perioperative Biobank to Define Perioperative Changes of Molecular Markers of Perioperative Organo-dysfunctions, Inflammation, Adverse Events and Disease Progression
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Anesthesia
- Sponsor
- Insel Gruppe AG, University Hospital Bern
- Enrollment
- 547
- Locations
- 1
- Primary Endpoint
- Assessing the change of the metabolic profile in the perioperative setting
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression. To better understand the perioperative impact the investigators aim to determine perioperative levels of molecular markers over time in the available samples and clinical data of the Bern perioperative Biobank (BPBB) cohort to finally increase quality of perioperative care of patients by permitting preventive measures to be taken early in patients at risk.
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 years and older
- •Written informed consent
- •Non-emergency surgery
- •Exclusion Criteria
- •Transient incapacity to consent or insufficient time (\< 6h) to consider study participation
- •No informed consent
- •Cognitive impairment/Patients unable to consent
- •Patients who retrospectively expressed their wish to be excluded
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Assessing the change of the metabolic profile in the perioperative setting
Time Frame: On postoperative day 1 during the morning round between 07:30-9:00am
Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.