Effects of Core Stability Training on Gait in Multiple Sclerosis Patients

Not Applicable

Completed

• Conditions: Gait Disorders, Neurologic; Multiple Sclerosis

• Registration Number: NCT03442049
• Lead Sponsor: Hacettepe University

Brief Summary

Gait and mobility are among the functions frequently affected in Multiple Sclerosis (MS) and have a negative impact on quality of life. Strength losses in lower limb muscles, ataxia, sensory problems and fatigue are the most important reasons of walking problems in patients with MS. In addition to loss of strength and tonus problems, especially biomechanical disorders can be seen on foot and this problem affects gatin and balance negatively. The stabilizing muscles, defined as the "core" region and enveloping the body like a corset, are active in the context of postural preparation prior to lower extremity movements and stabilize for the limb movements to be performed. The aim of this study was to investigate the effects of spinal stabilization exercises on walking performance, fatigue, plantar pressure distribution, balance, muscle strength and quality of life in patients with Multiple Sclerosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-01
• Primary Completion: 2016-02-20
• Study Completion: 2016-05-01
• Study First Submitted: 2018-01-25
• Status Verified: 2018-02
• Study First Submitted QC: 2018-02-15
• Last Update Submitted: 2018-02-15
• Study First Posted: 2018-02-22
• Last Update Posted: 2018-02-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

• Older than 18 years old
• EDSS score is between 3-5,5
• Patients who did not take corticosteroid therapy within three months
• Patients who get at least 24 points from the Mini Mental Test were included in the study.

Exclusion Criteria

• Patients who had an acute MS attack or had an attack within the last three months.
• An orthopedic or systemic problem that would prevent participation in exercises
• Patients who were using walking orthoses or walking aids were not included in the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
6 Minutes Walk Test	Change from Baseline 6 Minutes Walking Distance at 6 weeks.	Maximum Walking Distance in 6 Minutes
Plantar Pressure Distribution	Change from baseline peak pressure and contact area values at 6 weeks	Contact area values of 10 subregions under the foot
Modified Borg Scale	Change from Baseline Fatigue Score at 6 weeks.	Evaluating fatigue between the scores of 0 and 10. "0" means no fatigue at all. "10" means maximal fatigue.
Multiple Sclerosis Quality of Life Scale	Change from baseline mental and physical quality of life scores at 6 weeks	Quality of life assessment with 54 questions about mental and physical health in daily life activities.

Secondary Outcome Measures

Name	Time	Method
Muscle strength with hand held dynamometer	Change from baseline muscle strength at 6 weeks	Ankle Dorsiflexors Muscle Strength
MiniBESTest	Change from baseline MiniBESTest scores at 6 weeks	Static and dynamic balance evaluation. This test includes 14 items and maximum score is 28. 28 points means best balance status.
Dynamic Gait Index	Change from baseline Dynamic Gait Index scores at 6 weeks	Dynamic balance evaluation especially walking balance. This test includes 8 items and maximum score is 24. Maximum score means best dynamic balance status.