The effect of different types of exercise on the prevention of ischaemia-reperfusion injury: a pilot study

Completed

• Conditions: Ischaemia reperfusion injury; vascular damage; 10047079

• Registration Number: NL-OMON48280
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

- Adults >18 years, <40 years.
- BMI < 30kg/m2
- Recreational athlete (i.e. minimal 1h/week exercise, maximal 5 days/week of exercise)
- Mentally able/allowed to give informed consent

Exclusion Criteria

- Presence of an absolute contra-indication for the performance of exercise (see also SOP Inspanningstest Department of Physiology):
- Acute myocardial infarction (3-5 days)
- Unstable angina
- Uncontrolled arrhythmias causing symptoms or hemodynamic compromise
- Active endocarditis
- Acute myocarditis or pericarditis
- Symptomatic severe aortic stenosis
- Uncontrolled heart failure
- Acute pulmonary embolus or pulmonary infarction
- Thrombosis of lower extremities
- Suspected dissecting aneurysm
- Uncontrolled asthma
- Pulmonary edema
- Respiratory failure
- Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis)
- Mental impairment leading to inability to cooperate

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in endothelial function (measured with flow mediated dilation) before<br /><br>and after ischaemia reperfusion injury(induced by 15-minute ischaemia to the<br /><br>forearm, followed by 20-minutes of reperfusion). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma nitrite/nitrate levels, (anti)inflammatory markers, metabolomics as will<br /><br>be performed in plasma.</p><br>