Randomized trial of spatially targetted malaria control to virtually eliminate malaria in areas of very low incidence and patchy transmission in Senegal.

niversite Cheikh Anta Diop, Dakar0 个研究点目标入组 497,379 人开始时间: 2013年6月27日最近更新: 2023年5月29日

适应症

试验速览

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•In each year of intervention, hotspot areas will be defined on the basis of the previous year¿s malaria cases. Within the hotspots in the intervention clusters, all households will be offered IRS spraying, and all persons over 3 months of age will be included in MDA and MSAT rounds.
•For the cross sectional survey each year, participants (all ages, both genders) will be selected randomly from the DSS database, all selected persons who consent to participate will be included. Pregnant women will be eligible for treatment with DHA-PQ if they are in the second or third trimester (more than 3 months since last menstrual period, or after quickening (first movements of the baby detected by the mother).

•Health posts in urban and semi-urban areas will be excluded. Households will be excluded from IRS if the head of the household does not consent. They will remain eligible for other aspects of the trial.
•In MDA and MSAT arms, households will not be included if the head of the household refuses. Individuals will be included only if they (or their mother/carer) consent.
•In the MDA arm of the trial, treatment with DHA-PQ will be withheld from babies under 3 months of age, from person with history of allergy to ACTs, from persons who are unwell and require medical attention, and from women who say they are pregnant. Persons who are unwell will be referred to the nearest health facility.
•In the MSAT arm, babies under 3 months of age will not be screened. Women in the first trimester of pregnancy (pregnant for less than 3 months) and women who believe they may be pregnant, who test positive for malaria by RDT, and persons with known allergy to ACTs who test positive by RDT, will not be treated with DHA-PQ, they will be given a referral card with their test result and referred for treatment at the nearest health post. Persons who are unwell with fever will be tested and treated with DHA-PQ if positive, or referred, in accordance with national guidelines for community case

发起方

niversite Cheikh Anta Diop, Dakar