Effect of anesthesia on neutrophil induced cell death in orthopedic trauma surgeries
Not Applicable
- Conditions
- Health Condition 1: S324- Fracture of acetabulum
- Registration Number
- CTRI/2020/01/022644
- Lead Sponsor
- AIIMS Intramural funds
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Male or female arriving in OT for pelvic-acetabular injury and fracture shaft femur.
2. 18- 60 years of age.
3. ASA Grade I/II patients i.e. with minimal risk of anesthesia as per standard practices.
Exclusion Criteria
1. Signs of infection present.
2. History of being operated within 3 months for any ailment.
3. Any allergy to anesthetic/ local anesthetic drugs.
4. Redo surgery.
5. Patient on immunosuppressant therapy.
6. History of inflammatory disorder.
7. Patients with difficult airway requiring fiber-optic intubation.
8. Contraindication to regional anesthesia i.e.platelet count < 80,000/cmm or PT INR > 1.5
9. Spine pathology present.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary Outcome: Influence of different anesthetic techniques on NETosis and their components and on development of SIRS.Timepoint: 3 years
- Secondary Outcome Measures
Name Time Method 1: In-Vivo quantification of NETs, MPO & Histone at consecutive time points during and after isolated major orthopaedic trauma surgeries. <br/ ><br>2: Optimal timing for nonlife-saving surgical intervention after trauma. <br/ ><br>3: Damaged tissue healing and repair. <br/ ><br>4: Second hit related MOF. <br/ ><br>5: Hospital length of Stay. <br/ ><br>Timepoint: 3 years