Measurement of the Energy Metabolism of Peritoneal Dialysis Patients
- Conditions
- Renal Failure
- Interventions
- Behavioral: automated DPBehavioral: Calorimetric chamber
- Registration Number
- NCT03347305
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome.
The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.
- Detailed Description
The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome.
The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 24
-
Patients Group DPA
- Male patients
- Aged 18 to 70 years
- With end-stage renal disease
- Treated by automatic peritoneal
- Social security cover
- Without acute events in the 3 months prior to inclusion
- PCR < 30 mg/L
- Written informed consent
- Baecke activity score from 5 to 10
Healthy Volunteers
- Male patients
- Aged 18 to 70 years
- Patients matched by lean body mass (± 2 kgs) and age (± 5 years)
- Having a glomerular filtration rate estimated with the formula CKD-EPI creatinine > 60 mL / min / 1.73 m 2
- PCR < 3 mg/L
- Social security cover
- Written informed consent
- Baecke activity score from 5 to 10
-
• - Female
- Type 1 or 2 diabetes requiring a antidiabetic treatment
- Decompensated heart failure
- Smoking more than 5 cigarettes a day
- Alcoholic patients, drinking more than 3 glass of alcohol a day
- Patient Corticotherapy in progress
- Patient with evolutive acute pathology
- Person who has participated in another study within the last 30 days or is in period of exclusion on the National File of Healthy Volunteers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Patients Group DPA automated DP The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber Healthy Volunteers Calorimetric chamber The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber
- Primary Outcome Measures
Name Time Method Energy expenditure measured by indirect calorimetry in a calorimetric chamber at day 1 Energy expenditure measured by indirect calorimetry in a calorimetric chamber
- Secondary Outcome Measures
Name Time Method Actimetry at day 1 Estimated ambulatory energy expenditure from heart rate
respiratory quotient (RQ) at day1 Nature of the oxidized nutrients determined from the measurement of the respiratory quotient
HGPO at day 1 Charges of blood insulin concentration, and glucose in response to oral glucose load
Trial Locations
- Locations (1)
CHU Clermont-Ferrand
🇫🇷Clermont-Ferrand, France