Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4

Phase 2

Completed

• Conditions: Opioid-Related Disorders; Substance-Related Disorders
• Interventions: Drug: 20% N2O; Drug: 30% N2O; Drug: 0% N2O; Drug: 10% N2O; Drug: 40% N2O

• Registration Number: NCT00000252
• Lead Sponsor: University of Chicago

Brief Summary

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.

Detailed Description

Not available

Study Timeline

• Study Start: 1994-06
• Primary Completion: 1996-06
• Study Completion: 1996-06
• Study First Submitted: 1999-09-20
• Study First Submitted QC: 1999-09-20
• Study First Posted: 1999-09-21
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
20% N2O	20% N2O	Subjects will inhale 20% N2O
30% N2O	30% N2O	Subjects will inhale 30% N2O
0% N2O	0% N2O	Subjects will inhale 0% N2O
10% N2O	10% N2O	Subjects will inhale 10% N2O
40% N2O	40% N2O	Subjects will inhale 40% N2O

Primary Outcome Measures

Name	Time	Method
Psychomotor performance	During inhalation	Subjects will undergo psychomotor testing during 120 min inhalation session of each intervention
Cognitive performance	During inhalation	Subjects will under cognitive testing during 120 minute inhalation session of each intervention

Trial Locations

Locations (1)

University of Chicago, Anesthesia & Critical Care; 🇺🇸 Chicago, Illinois, United States