Tinidazole Versus Cefazolin Antibiotic Prophylaxis of Vaginal and Abdominal Hysterectomy
- Conditions
- Hysterectomy
- Interventions
- Registration Number
- NCT00787553
- Lead Sponsor
- University of Campinas, Brazil
- Brief Summary
Purpose: to compare the efficacy of tinidazole and cefazolin on the prophylaxis of the febrile and infectious morbidity after vaginal or abdominal hysterectomy. Methods: A randomized clinical trial carried out at the Women's Integrated Healthcare Center (CAISM)/UNICAMP, Campinas, Brazil. Women undergoing to total vaginal or abdominal hysterectomy were randomly enrolled into one of these three groups of antibiotic prophylaxis: tinidazole, cefazolin or an association of both.
- Detailed Description
A randomized clinical trial carried out at the Women's Integrated Healthcare Center (CAISM)/UNICAMP, Campinas, Brazil, to compare the efficacy of tinidazole and cefazolin on the prophylaxis of the febrile and infectious morbidity after vaginal or abdominal hysterectomy. Women undergoing to total vaginal or abdominal hysterectomy were randomly enrolled into one of these three groups of antibiotic prophylaxis: tinidazole, cefazolin or an association of both.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 75
- women undergoing to hysterectomy due to non-oncologic causes
- previous pelvic infection
- antibiotic use within 7 days before surgery
- study drugs allergy
- immuno-incompetence
- urinary tract infection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description cefazolin plus tinidazole cefazolin plus tinidazole - cefazolin cefazolin - tinidazole tinidazole -
- Primary Outcome Measures
Name Time Method Post-operative infection one month after surgery
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Campinas
🇧🇷Campinas, SP, Brazil