Association Between Genotype, Polyphenol Gut Microbiota Metabotypes, and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 423
- 试验地点
- 1
- 主要终点
- Polyphenol metabotypes
研究概览
简要总结
The objective of this study is to investigate the possible association between 60 SNPs related to obesity, metabolism and cardiovascular disease with BMI, intestinal microbiota and adherence to the Mediterranean diet in a cohort of children and adolescents from the southeast of Spain.
详细描述
The objective of this study is to investigate the possible association between 60 single nucleotide polymorphisms (SNPs) related to obesity, metabolism and cardiovascular disease with the body mass index (BMI), intestinal microbiota related to the metabolism of polyphehnos and adherence to the Mediterranean diet in a cohort of children and adolescents from the southeast of Spain.
The volunteers (n=423) with ages ranging from 5 to 18 years consumed for three days a daily serving of walnuts (30g) and provided a sample of urine (to determine mirobial-derived metabolites from walnut polyphenols) as well as a swab specimen from the inner cheek to provide DNA for further genotyping.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 5 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy individuals aged 5 to 18 years.
- •Informed consent signed by the parent / legal representative, and by volunteers who are already 18 years old.
排除标准
- •Known or suspected allergy or intolerance to nuts or pomegranate.
- •Intake of antibiotics 1 month before the start of the study.
- •If the participant could perceive stress or psychological damage due to his participation.
- •Any other circumstance different from previous ones (illness, etc.), according to which it is considered that the intervention in the study may involve some type of affectation.
研究组 & 干预措施
Child-teenagers-walnuts-pomegranate
Intake of walnuts or pomegranate juice for 3 days
干预措施: Walnuts (Other)
Child-teenagers-walnuts-pomegranate
Intake of walnuts or pomegranate juice for 3 days
干预措施: Pomegranate juice (Other)
结局指标
主要结局
Polyphenol metabotypes
时间窗: 1 to 3 months
Type of ellagic acid-derived microbial metabolites in urine
次要结局
- Genotype(1 to 6 months)
- Adherence to Mediterranean diet(1 to 3 months)
研究者
Juan Carlos Espín de Gea
Research Professor
National Research Council, Spain