Anticholinergic Risk Scale and Resource Use After Elective Noncardiac Surgery

Completed

• Conditions: Anti Cholinergics; Length of Stay; Aged; Surgical Procedure, Operative; Epidemiology
• Interventions: Other: anticholinergic risk scale

• Registration Number: NCT03151616
• Lead Sponsor: Ottawa Hospital Research Institute

Brief Summary

This study investigates the association of preoperative anticholinergic medication exposure with healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program

Detailed Description

Multilevel multivariable regression analysis will be used to investigate the adjusted association between preoperative Anticholinergic Risk Scale and postoperative healthcare resource utilization. Sensitivity analyses will be used to evaluate the robustness of the primary analysis.

Study Timeline

• Study Start: 2003-04-01
• Primary Completion: 2014-03-31
• Study Completion: 2014-03-31
• Study First Submitted: 2017-05-10
• Study First Submitted QC: 2017-05-11
• Study First Posted: 2017-05-12
• Status Verified: 2024-10
• Results First Submitted: 2024-11-22
• Results First Submitted QC: 2024-11-22
• Last Update Submitted: 2024-11-22
• Results First Posted: 2025-01-10
• Last Update Posted: 2025-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 244976

Inclusion Criteria

• at least 66 years old on the day of surgery
• Intermediate to high risk elective noncardiac surgery

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Moderate anticholinergic exposure	anticholinergic risk scale	People with an anticholinergic risk scale score of 1-2
High anticholinergic exposure	anticholinergic risk scale	People with an anticholinergic risk scale score of \>=3

Primary Outcome Measures

Name	Time	Method
Hospital Length of Stay	date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first	Number of days in hospital after surgery

Secondary Outcome Measures

Name	Time	Method
Costs of Care	date of surgery up to 90 days after surgery	Costs related to medical care paid for by the provincial health insurance system
Institutional Discharge	date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first	A discharge location at the end of the surgical episode of care that is not back to the patient's original residence (specifically respite or long term care)
Mortality	from day of surgery up to 90 days after surgery	death from any cause
Hospital Readmission	From the date of hospital discharge to 30 days after the date of discharge	Acute hospital readmission after discharge from index hospitalization

Trial Locations

Locations (1)

Ottawa Hospital Research Institute; 🇨🇦 Ottawa, Ontario, Canada