Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine
- Registration Number
- NCT02430272
- Lead Sponsor
- Inje University
- Brief Summary
Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents.
The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 84
- American Society of Anesthesiologists (ASA) Physical Status classification I
- underwent surgery between 8 to 9 am
- undergoing ambulatory anesthesia with ketamine
- who required endotracheal intubation
- who were administered with medications other than ketamine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Anticholinergic premedication Glycopyrrolate Premedication with 0.005mg/Kg of glycopyrrolate
- Primary Outcome Measures
Name Time Method Body temperature every 30 minutes from base line ( up to 90min ) measured body temperature at three times in both ears and the highest value was selected.
- Secondary Outcome Measures
Name Time Method Oral secretion (VAS) up to operative end Oral secretion during the whole procedure was recorded by the researcher
Trial Locations
- Locations (1)
Ilsan Paik hospital
🇰🇷Goyang-si, Gyeonggi-do, Korea, Republic of