Comparative effect of Narayana ghrita and Jeerakadhya ghrita on Hyperacidity

Not yet recruiting

Conditions: Functional dyspepsia. Ayurveda Condition: AMLAPITTAM,

Registration Number: CTRI/2022/06/043618

Lead Sponsor: BVVS Ayurveda Medical College and Hospital

Brief Summary: *Amlapitta* is condition where *Pitta* is accumulated previously from the self aggravating causes, gets *Vidagdha* due to *Virudha, Dustha, Amla, Vidahi, Pittakar Ahara* and *Drava* like *Phanita, Kulattha, Ikshu Vikara, Bhristha Dhanya, Pulaka* etc. In further days due to repeated *Nidanas* it get *Shuktatva* residing in *Aamashaya*. *Amlapitta* has symptoms like *Avipaka, Klama, Utklesh, Tiktaamlodgara, Gouravata, Hritkantha Daha, Aruchi etc1.*

*Urdhwaga* *Amlapitta* can be correlated with Dyspepsia in modern science. Its symptoms are like nausea, indigestion , heart burn, sour and bitter belchings, post-prandial fulness etc2,3,4.

Prevalence rate of Dyspepsia in India is 30.4%. Most common symptoms included Abdominal fullness (24%), Abdominal pain (13.6%), Heart burn(10.7%) & Belching(10.6%)5

Dyspepsia affects the personal, mental, professional and economical status of individual life. Treatment modality includes administration of Proton pump inhibitors, H2-blockers and Antacids. Prolonged use of these drugs may cause loss of appetite, nausea, constipation etc6. So these drugs have restrictions of prolonged usage. Thus *Ayurveda* has scope for this treatment.

In *Ayurvedic* classics, various therapies like *Vamana, Virechana, Snehapana*, *Rakta Mokshana, Shamana Chikitsa* and *Rasayana* etc are mentioned to manage *Amlapitta*. *Ghrita* is having unique quality of *Sanskarasya Anuvartanaat*, ability to imbibe the qualities of herbs by which it is being processed without loosing itâ€™s basic qualities. In *Amlapitta, Ghrita i*s mentioned as *Pathya.*7 Thus *Ghrita* is utilized as supreme media for drug administration. *Ghrita* is *Vata-Pittahara, Na Shleshma Vardhana, Daha Shamaka and Agnideepana.* hence it is used in the management of *Amlapitta*8

*Amlapitta* is *Pittapradhan* and *Saamavyadhi.* *Kledaka Kapha* and *Pachaka Pitta* are *Drava* in dominancy. The *Dravatah Vriddhi* of *Pitta* reduces the *Tikshanata* of *Pachaka Pitta* as well as vitiates *Kledaka Kapha* leading to *Agnimandya* and unable to digest even little quantity of food. *Narayan Ghrita* contains ingredients like *Pippali, Shunthi* having properties like *Katu Rasa*, *Tikshna Guna, Ushna Virya & Madhura Vipaka. Katuki* is having *Tikta Rasa, Shita Virya, and Katu Vipaka* so used in *Vikruta Pitta* and *Kaphajanya Vikaras.* Itdoes *Deepana, Pachana, Rochana* and *Dosha Samshodhan*. Due to*Madhura Guna* of *Pippali* it acts as *Pittashamaka* and due to *Ushnata, Madhura Vipaka Vatanulomana* takes place*.* *Guduchi, Amalaki, Draksha* does the *Shamana* of *Udrikta Pitta*. *Ghrita* is having *Madhura Rasa, Madhura Vipaka, Sheeta Veerya, Pitta-Anilahara*, it is having *Agnideepaka Tridoshahara* property. By these properties it does the *Samprapti Vighatana* on *Amlapitta*. *Jeerakadhya Ghrita* contains *Jeeraka* which is *Agnideepaka*& *Dhanyaka* which is *Pittashamak*. By considering above qualities drugs are selected for the study of management of *Urdwaga* *Amlapitta.*

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

patients presenting with classical symptoms of Urdhwaga Amlapitta.

Exclusion Criteria

1)Patients with history of other chronic systemic illness 2)Established cases of Parinama shoola(gastric ulcer,duodenal ulcer),Annadrava shoola,Krimiroga and Arbuda 3)Pregnancy and Lactation.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Notify improvement in symptoms like tiktaamlodgara,hrith-kanta daha,utklesh,chardi,	15 days
avipaka,gouravata	15 days

Secondary Outcome Measures

Name	Time	Method
Relief from the symptoms like tiktaamlodgara(bitter and sour belchings),hrith-kantha daha(Heart burn),utklesh(Nausea),Chardi(vomiting),avipaka(indigestion),gouravata(post-prandial fullness)	20 days

Trial Locations

Locations (1): BVVS Ayurveda Medical College and Hospital Bagalkot
🇮🇳
Bagalkot, KARNATAKA, India
BVVS Ayurveda Medical College and Hospital Bagalkot
🇮🇳Bagalkot, KARNATAKA, India
Dr Shubhangini S Kolar
Principal investigator
7411499005
shubhssk77@gmail.com