A Study of the Effects of Intake of Two Cod Residual Meals on Glucose Regulation in Overweight and Obese Adults

Not Applicable

Completed

• Conditions: Overweight; Obesity
• Interventions: Dietary Supplement: Cod protein from presscake + stickwater; Dietary Supplement: Cod protein from presscake; Dietary Supplement: Control

• Registration Number: NCT01894542
• Lead Sponsor: University of Bergen

Brief Summary

The investigators have previously shown the intact protein from cod filet improves glucose regulation and serum lipid profile in overweight adults. A large amount of trimmings from various fish species such as cod is thrown away or sold at very low prices for animal feed, and analyses of the amino acid composition reveals that this can be a good protein source for humans. Two fractions are normally isolated from intact fish meal, i.e. water soluble and non-water soluble proteins. In the present study the investigators will compare these fractions, by studying their effects on glucose regulation in overweight/obese adults.

Detailed Description

Participants receive 6g per day of water soluble on non-water soluble cod protein as tablets for 8 weeks.

Study Timeline

• Study First Submitted: 2013-07-03
• Study First Submitted QC: 2013-07-09
• Study First Posted: 2013-07-10
• Study Start: 2013-08
• Primary Completion: 2014-12
• Study Completion: 2019-12
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-29
• Last Update Posted: 2022-04-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

• BMI>28
• healthy
• fasting blood glucose <7.0 mmol/L
• stable body weight with less than 5 kg fluctuation during the last 4 months

Exclusion Criteria

• known disease or metabolic disturbances related to overweight or obesity
• use of prescription medications that affect blood glucose, blood lipids or inflammatory status
• allergies towards fish or seafood
• undertaking a weight loss diet
• tobacco use exceeding >15 cigarettes/day
• pregnancy or breastfeeding
• high seafood consumption
• use of dietary supplements including cod liver oil or other marine fatty acids
• allergies towards fish, milk, egg

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cod protein from presscake + stickwater	Cod protein from presscake + stickwater	-
Cod protein from presscake	Cod protein from presscake	-
Control	Control	Control group will receive tablet containing only tablet fillers (the same as in the cod protein tablets).

Primary Outcome Measures

Name	Time	Method
Glucose tolerance	8 weeks	Serum glucose will be measured in fasting and postprandial state

Secondary Outcome Measures

Name	Time	Method
Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine	8 weeks	Concentrations of relevant metabolites and co-factors were measured in serum and urine
Gene expression	8 weeks	Changes in gene expression in adipose tissue related to the circulating markers of glucose regulation.
Amino acids and amino acid metabolites	8 weeks	Amino acids and amino acid metabolites will be measured in serum and urine

Trial Locations

Locations (1)

University of Bergen; 🇳🇴 Bergen, Norway