An 8 Week Study to Compare the Effects of Two Combinations of Water Soluble and Non-water Soluble Cod Residual Meals on Glucose Regulation in Overweight and Obese Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Bergen
- Enrollment
- 55
- Locations
- 1
- Primary Endpoint
- Glucose tolerance
Study Overview
Brief Summary
The investigators have previously shown the intact protein from cod filet improves glucose regulation and serum lipid profile in overweight adults. A large amount of trimmings from various fish species such as cod is thrown away or sold at very low prices for animal feed, and analyses of the amino acid composition reveals that this can be a good protein source for humans. Two fractions are normally isolated from intact fish meal, i.e. water soluble and non-water soluble proteins. In the present study the investigators will compare these fractions, by studying their effects on glucose regulation in overweight/obese adults.
Detailed Description
Participants receive 6g per day of water soluble on non-water soluble cod protein as tablets for 8 weeks.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 20 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •fasting blood glucose <7.0 mmol/L
- •stable body weight with less than 5 kg fluctuation during the last 4 months
Exclusion Criteria
- •known disease or metabolic disturbances related to overweight or obesity
- •use of prescription medications that affect blood glucose, blood lipids or inflammatory status
- •allergies towards fish or seafood
- •undertaking a weight loss diet
- •tobacco use exceeding >15 cigarettes/day
- •pregnancy or breastfeeding
- •high seafood consumption
- •use of dietary supplements including cod liver oil or other marine fatty acids
- •allergies towards fish, milk, egg
Arms & Interventions
Cod protein from presscake
Intervention: Cod protein from presscake (Dietary Supplement)
Cod protein from presscake + stickwater
Intervention: Cod protein from presscake + stickwater (Dietary Supplement)
Control
Control group will receive tablet containing only tablet fillers (the same as in the cod protein tablets).
Intervention: Control (Dietary Supplement)
Outcomes
Primary Outcomes
Glucose tolerance
Time Frame: 8 weeks
Serum glucose will be measured in fasting and postprandial state
Secondary Outcomes
- Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine(8 weeks)
- Gene expression(8 weeks)
- Amino acids and amino acid metabolites(8 weeks)
Investigators
Oddrun Anita Gudbrandsen
PhD
University of Bergen