Ghrelin Levels in Pancreatic Cancer Patients

Completed

• Conditions: Pancreatic Cancer
• Interventions: Procedure: Blood draw

• Registration Number: NCT00225745
• Lead Sponsor: Dartmouth-Hitchcock Medical Center

Brief Summary

The primary outcome measure for this study is plasma ghrelin level.

Detailed Description

The primary outcome measure for this study is plasma ghrelin level, and the two primary comparison are:

* Patients with cachexia versus patients without cachexia

* Patients with cachexia versus healthy controls

Study Timeline

• Study Start: 2004-04
• Study First Submitted: 2005-09-22
• Study First Submitted QC: 2005-09-22
• Study First Posted: 2005-09-26
• Primary Completion: 2013-10
• Status Verified: 2015-08
• Study Completion: 2015-09
• Last Update Submitted: 2015-10-12
• Last Update Posted: 2015-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• Histological or cytological proof of pancreatic adenocarcinoma
• The control are will include healthy age-matched patients without cancer
• The test arm will include patients with pancreatic cancer and they will divided into two groups: those with and without weight loss
• Patients must have recovered from any major infections and/or surgical procedures

Exclusion Criteria

• Patients with other serious medical illness like congestive heart failure, thyroid disease,liver disease or renal failure - conditions that will alter their nutritional state
• Patients on appetite stimulant and those receiving total parenteral nutrition
• Patients who have undergone gastrectomy or those who have gastric ulcers
• Patients receiving active chemotherapy
• No prior malignancy except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer or for which patient has been disease free for at least five years.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
2	Blood draw	Healthy controls
1	Blood draw	Pancreatic cancer patients

Primary Outcome Measures

Name	Time	Method
To evaluate plasma ghrelin levels in patients with pancreatic cancer and compare with age matched controls	prior to treatment

Secondary Outcome Measures

Name	Time	Method
To investigate the role of ghrelin in pathophysiology of cancer cachexia	prior to treatment
To generate hypotheses for future studies and treatment based on the findings	prior to treatment

Trial Locations

Locations (1)

Dartmouth Hitchcock Medical Center/Norris Cotton Cancer Center; 🇺🇸 Lebanon, New Hampshire, United States