Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue

Early Phase 1

Completed

• Conditions: Healthy
• Interventions: Drug: Acyl ghrelin; Drug: Placebo (Ringer acetate)

• Registration Number: NCT01595373
• Lead Sponsor: Esben Thyssen Vestergaard

Brief Summary

The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-05-07
• Study First Submitted QC: 2012-05-08
• Study First Posted: 2012-05-10
• Study Start: 2012-06
• Primary Completion: 2012-09
• Status Verified: 2013-01
• Study Completion: 2013-01
• Last Update Submitted: 2013-01-15
• Last Update Posted: 2013-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• healthy male
• age 18-65 years (included)
• Body mass index 20-25 (included)

Exclusion Criteria

• alcohol abuse
• malignant disease
• use of any medicine except otc painkillers
• any disease recognized
• participation in a trial using radioactive isotopes within the last 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Ghrelin	Acyl ghrelin	Ghrelin
Placebo	Placebo (Ringer acetate)	Ringer acetate is used for placebo.

Primary Outcome Measures

Name	Time	Method
Interstitial concentrations of glycerol	Interstitial concentrations of glycerol at t=120 minutes

Secondary Outcome Measures

Name	Time	Method
Interstitial concentrations of lactate	Interstitial concentrations of lactate at t=120 minutes
Interstitial concentrations of glucose	Interstitial concentrations of glucose at t=120 minutes

Trial Locations

Locations (1)

Aarhus University Hospital; 🇩🇰 Aarhus, Denmark