The Acute T-Rex (Timing of Resistance Exercise) Study

Not Applicable

Recruiting

• Conditions: Diabetes Mellitus, Type 2; Sleep Disturbance; Glucose Intolerance; Insulin Sensitivity; Insulin Resistance; Overweight or Obesity
• Interventions: Behavioral: Resistance Exercise Timing

• Registration Number: NCT06366399
• Lead Sponsor: University of Utah

Brief Summary

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-11-15
• Study First Submitted: 2024-01-31
• Study First Submitted QC: 2024-04-10
• Study First Posted: 2024-04-15
• Status Verified: 2025-03
• Last Update Submitted: 2025-04-01
• Last Update Posted: 2025-04-03
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Men and women, all ethnicities, aged 50-74 years
• BMI ≥25 kg/m² and <45 kg/m²
• Weight stable (less than 5% change in the past 6 months)
• Generally healthy individuals
• Not meeting recommended activity guidelines for aerobic or resistance exercise

Exclusion Criteria

• Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease
• Cancer treatment in the past 5 years
• Untreated thyroid disease or other medical conditions affecting weight or energy metabolism
• Current use of weight loss medication or other medications likely to impact energy balance
• Bariatric surgery or extensive bowel resection in the past 2 years
• Current or recent history (past 2 years) of eating disorder
• Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders
• Non-English speaking
• HbA1c >6.5%

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
PM Resistance Exercise	Resistance Exercise Timing	Resistance Exercise intervention taking place in the PM
AM Resistance Exercise	Resistance Exercise Timing	Resistance Exercise intervention taking place in the AM

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity	1 day	Insulin sensitivity will be calculated using the Matsuda Insulin Sensitivity Index

Secondary Outcome Measures

Name	Time	Method
Sleep Duration	1 day	Sum of time spent in stage 1, stage 2, stage 3 and rapid eye movement stage (REM) as assessed via polysomnography.

Trial Locations

Locations (1)

University of Utah HPER E Buildling; 🇺🇸 Salt Lake City, Utah, United States