Survey of Non-resuscitation Fluids in Septic Shock
- Conditions
- Septic Shock
- Registration Number
- NCT03438097
- Lead Sponsor
- Region Skane
- Brief Summary
The objective of this study is to survey the type and the amount of non-resuscitation fluids that patients with septic shock receives during their first 5 days of ICU admission.
- Detailed Description
Background: Several studies indicate that a large part of the fluid intake in intensive care patients consists of fluids that are given for indications other than volume expansion. However, the type of non-resuscitation fluids that hemodynamically unstable ICU patients receive has not been well characterized.
Methods: A multicenter observational cohort study. Baseline data including, sex, age, physiological data at admission, source of sepsis, illness severity, and ICU and hospital mortality will be collected.
Fluids administered during the first five days of ICU admission will be registered. Fluids used as vehicle to administer drugs will be regarded as non-resuscitation fluids and will be characterized in detail. All glucose solutions will be regarded as non-resuscitation fluids. Crystalloids delivered at a rate of \< 5 ml/kg/h will be considered as non-resuscitation fluids. Parenteral nutrition will be regarded as non-resuscitation fluids. Crystalloids delivered at a rate of ≥ 5 ml/kg/h will be considered to be resuscitation fluids. Blood products and colloids will be regarded as resuscitation fluids.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- Septic shock per SEPSIS-3 criteria within 24 hrs of ICU admission
- Informed consent from patient or next of kin if required by local ethical review Board
• Lack of informed consent (see above)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Type, indication and volume of fluids given to septic shock patients for other reasons than circulatory support. First five days in ICU Type of fluid is defined as either 0.9% normal saline, glucose, Ringers acetate/lactate, enteral nutrition, parenteral nutrition or sterile water.
Indication is defined as vehicle, nutrition, maintenance or other. Volume will be reported in ml.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (8)
ICU Ystad Hospital
🇸🇪Ystad, Sweden
ICU Helsingborg Hospital
🇸🇪Helsingborg, Sweden
ICU Skane University Hospital
🇸🇪Malmö, Sweden
ICU Halmstad Hospital
🇸🇪Halmstad, Sweden
ICU Kristianstad Hospital
🇸🇪Kristianstad, Sweden
St Paul's Hospital
🇨🇦Vancouver, British Columbia, Canada
Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
Department of Infections Diseases
🇸🇪Malmö, Sweden