Defining the Normal Range for Maximal Sniff Diaphragm Thickening Fraction
- Conditions
- Diaphragm
- Registration Number
- NCT03129386
- Lead Sponsor
- University Health Network, Toronto
- Brief Summary
This study is investigating the normal range of maximal diaphragm thickness during a sniff inspiratory manoeuvre using ultrasound in healthy subjects stratified by age and gender.
- Detailed Description
Diaphragm dysfunction is associated with poor clinical outcomes in critically ill patients but is difficult to diagnose. Traditionally, diaphragm function is measured by evaluating inspiratory muscle strength via maximal inspiratory pressure (MIP). However, this technique relies on a volitional maximal effort and can be challenging for patients to perform.
An alternative to measuring inspiratory muscle strength is the sniff inspiratory pressure approach. During short, sharp sniffs, the diaphragm is maximally activated.
Currently, there are no reported values of the normal range of maximal diaphragm thickness during a sniff maneuver. This study will define the normal range of values for sniff maximal diaphragm thickening fraction, maximal thickening against an occluded airway, and diaphragm thickening during resting tidal breathing in healthy subjects.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Over 18 years of age
- Antecedent history of neuromuscular or cardiorespiratory disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sniff diaphragm thickening fraction Day 1 Thickening of the diaphragm during an inspiratory sniff
Maximal diaphragm thickening fraction Day 1 Thickening of the diaphragm during a maximal inspiratory effort
Resting tidal thickening fraction Day 1 Thickening of the diaphragm during resting tidal breathing
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Health Network
🇨🇦Toronto, Ontario, Canada