Comparative Efficacy of Propofol Lidocaine Mixture alone with Fentanyl Pretreatment and Ondansetron Pretreatment for Propofol Lidocaine Mixture to Reduce Propofol induced Pain On Injection: A Double-Blinded Randomized Controlled Trial
Phase 4
Recruiting
- Conditions
- Patients undergoing general anesthesia.Lidocaine, Fentanyl, Propofol, Ondansetron, Injection pain
- Registration Number
- TCTR20230222006
- Lead Sponsor
- eurological Institute of Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 111
Inclusion Criteria
1. Age 18 - 65 years
2. Undergoing general anesthesia
3. Elective surgery
4. ASA physical status I or II
Exclusion Criteria
1. History of chronic pain
2. The patient has a history of allergy to propofol, eggs, lidocaine, fentanyl, or ondansetron.
3. Patients with liver disease
4. Patient has communication problems
5. The patient received anxiolytics or painkillers on the morning of the surgery.
6. Body mass index
greater than or equal to 30 kilograms per square meter
7. Rapid sequence intubation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Verbal Numerical Rating Scale and Behavior pain scale are recorded immediately after the propofol injection immediately after the propofol injection Verbal Numerical Rating Scale and Behavior pain scale
- Secondary Outcome Measures
Name Time Method incidence of adverse events; hypotension, bradycardia, and sedation. at 3 minutes after normal saline, fentanyl, ondansetron injection and 1 minute after propofol lidocaine mixture injection Patient reported outcome using a question. Clinical signs and hemodynamic changes were observed.