Helium Oxygen Mixture in the Treatment of Meconium Aspiration Syndrome

Not Applicable

Completed

• Conditions: Neonatal Meconium Aspiration
• Interventions: Device: helium oxygen mixture

• Registration Number: NCT02620891
• Lead Sponsor: Ma Juan

Brief Summary

Helium-oxygen mixture(heliox) was suggested to be beneficial in meconium aspiration syndrome in previous studies，but the evidence was limited．The aim of the study was to assess the effectiveness of synchronize intermittent mandatory ventilation (SIMV) with heliox (70% helium and 30% oxygen) on length of ventilation(LoV) and cardiopulmonary protection in meconium aspiration syndrome.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-02-01
• Study First Submitted: 2015-11-12
• Study First Submitted QC: 2015-12-02
• Study First Posted: 2015-12-03
• Primary Completion: 2017-02-20
• Study Completion: 2017-04-01
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-03
• Last Update Posted: 2020-01-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Subject has the diagnosis of neonatal meconium aspiration syndrome
• Subject has Synchronous instruction ventilation

Exclusion Criteria

• History of congenital or hereditary disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
experimental group	helium oxygen mixture	Using helium oxygen mixture

Primary Outcome Measures

Name	Time	Method
blood gas analysis	48 hour

Secondary Outcome Measures

Name	Time	Method
Inflammatory response index (IL-6,IL-8, TNF-a,CRP)	6 hour

Trial Locations

Locations (1)

Department of Pediatrics, Daping Hospital, Third Military Medical University; 🇨🇳 Chongqing, Chongqing, China