FRACTIONAL CO2 LASER VERSUS MICRONEEDLING WITH PLATELET RICH PLASMA IN PATIENTS WITH ACNE SCARS - A RANDOMIZED CONTROL TRIAL
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- to compare the efficacy of fractional CO2 laser and microneedling, by using dermaroller with PRP in patients with facial atrophic acne scars by using Arora Swati et al. grading system before and after the treatment.
研究概览
简要总结
These days a lot of treatment modalities are available for the treatment of acne scars like medical therapy, chemical agents, surgical therapy, mechanical devices, laser and energy-based devices, tissue augmentation and regenerative procedures.
One of the most accepted treatment for acne scars is Fractional CO2 laser. It helps in skin rejuvenation, decreases the depth of defect and has clinically favorable outcome.
By performing microneedling with the help of a dermaroller we are basically stimulating the migration and proliferation of fibroblasts which further results in collagen deposition hence decreasing the depth of defect and thus correcting the atrophic acne scar. Platelet rich plasma, is platelets concentrate present in a small volume of plasma. Present with a lot of growth factors and cytokines thus playing an important role in tissue repair and promoting tissue regeneration. Previously studies have been done comparing various modalities on acne scars, but there is paucity of data between comparison of fractional CO2 laser and microneedling by using dermaroller along with PRP for facial atrophic acne scars, hence this study is being planned to be done
研究设计
- 研究类型
- Interventional
- 分配方式
- Stratified randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 35.00 Year(s)（—）
- 性别
- All
入选标准
- •PATIENTS AGED BETWEEN 18-35 YEARS OF AGE GROUP PRESENTING WITH FACIAL ATROPHIC ACNE SCARS AND HAVING REALISTIC EXPECTATIONS.
排除标准
- •1.ISOTRETINOIN USE FOR PAST THREE MONTHS.
- •2.ACTIVE LESIONS OF ACNE AND HERPES SIMPLEX.
- •3.PATIENTS WITH HISTORY OF BLEEDING DIATHESIS.
- •4.PATIENTS ON ORAL ANTI COAGULANTS OR ACNE INDUCING DRUGS.
- •5.PREGNANT WOMEN.
- •6.PATIENTS WITH HYPERTROPHIC SCARRING OR KELOIDAL TENDENCY.
- •7.SYSTEMIC ILLNESSES E.G. COLLAGEN AND VASCULAR DISEASES,UNCONTROLLED DIABETES MELLITUS, AND NEUROMUSCULAR DISORDERS.
- •8.PARTIENTS WITH HISTORY OF INJECTIONS OF COLLAGEN, OR OTHER INJECTABLE FILLERS WITHIN PAST 6 MONTHS.
结局指标
主要结局
to compare the efficacy of fractional CO2 laser and microneedling, by using dermaroller with PRP in patients with facial atrophic acne scars by using Arora Swati et al. grading system before and after the treatment.
时间窗: at the end of the treatment.
次要结局
- 1.To assess the demographic characteristics of patients having facial atrophic acne scars.(2. To assess the clinical improvement in grading of facial acne scars in both the groups.)