Correlation of antiviral molecules with viruses in gum diseases
- Conditions
- Health Condition 1: R893- Abnormal level of substances chiefly nonmedicinal as to source in specimens from other organs, systems and tissues
- Registration Number
- CTRI/2019/01/016854
- Lead Sponsor
- Dr Shivaprasad BM
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Healthy subjects should be systemically healthy and showing absence of clinical manifestations of periodontal disease.
2.Chronic periodontitis patients having at least 20 natural teeth and minimum of six teeth with periodontal pockets >= 5mm and clinical attachment level >= 3-4 mm.
3.Generalised aggressive periodontitis patients with clinical attachment level >= 5mm affecting at least three teeth other than first molars and incisors and moderate to severe bone loss as assessed by radiographs.
4.All the patients should be systemically healthy and should not have received
periodontal treatment for at least 6 months prior to the clinical examination and sampling.
1.Smokers.
2.Systemic diseases like diabetes mellitus, heart diseases, rheumatoid arthritis, hepatitis and other systemic diseases that can alter the course of periodontal disease.
3.Diseases of oral hard and soft tissue except caries and periodontitis.
4.Subjects on any medication taken within the last 6 months which may alter the periodontal status.
5.Pregnant and lactating mothers.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method levels of interferon lambdas expression in gingival crevicular fluid and gingival tissue samples of chronic and aggressive periodontitis patients and to correlate with herpes virusesTimepoint: levels of interferon lambdas expression in gingival crevicular fluid and gingival tissue samples of chronic and aggressive periodontitis patients and to correlate with herpes viruses assessed immediately after collection at baseline
- Secondary Outcome Measures
Name Time Method Gingival index <br/ ><br>clinical attachment level <br/ ><br>probing pocket depth of chronic and aggressive periodontitis patientsTimepoint: Gingival index <br/ ><br>clinical attachment level <br/ ><br>probing pocket depth of chronic and aggressive periodontitis patients assessed at the time of baseline