Determinants of salt taste in healthy volunteers and patients with chronic kidney disease
- Conditions
- chronic kidney disease10029149
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
The patient group:
- Adult (>= 18 years)
- CKD (eGFR 15-44 ml/min/1.73 m2)
The group of healthy volunteers:
- Adult (>= 18 years)
Exclusion Criteria
The exclusion criteria for the CKD patients:
- smoking
- any mouth disease
- Diabetes mellitus
- Use of any of the following drugs: clopidogrel, amiodaron, flecainide,
sotalol, propafenon.
- intellectual disability
The exclusion criteria for the healthy volunteers:
- smoking
- any mouth disease
- Hypertension (difined as office blood pressure > 140/90 mmHg)
- Reduced eGFR, albuminuria, or a known kidney disease
- Diabetes mellitus
- Intellectual disability
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Salt-sensitivity (as determined by salt taste testing), 24-hour blood pressure,<br /><br>24-hour urinary excretion of sodium, plasma renin and aldosterone<br /><br>concentrations.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- To correlate salt sensitivity thresholds to blood pressure, plasma renin and<br /><br>aldosterone levels.<br /><br>- To correlate salt sensitivity thresholds to differences in the salivary<br /><br>proteome.<br /><br>- To correlate salt sensitivity thresholds to the ability to activate ENaC in a<br /><br>heterologous expression system (Xenopus oocytes).</p><br>