Comparison of Quality of Recovery Between Remimazolam and Propofol Anesthesia in Patients Undergoing Arthroscopic Meniscectomy

Not Applicable

Completed

• Conditions: Adult Patients 19 or Older Scheduled for Elective Arthroscopic Meniscectomy
• Interventions: Drug: Propofol TIVA; Drug: Remimazolam TIVA

• Registration Number: NCT05280236
• Lead Sponsor: Yonsei University

Brief Summary

This study aims to compare quality of recovery after surgery and anesthesia between patients undergoing arthroscopic meniscectomy under general anesthesia with either propofol or remimazolam based total intravenous anesthesia. This study is a randomized trial with a 50% probability of being assigned to either group. Randomization will be done by an anesthesiologist not involved in anesthesia or postoperative outcome assessment. Patients and the investigator in charge of postoperative outcomes assessment will be blinded to group allocation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-03-06
• Study Start: 2022-03-14
• Study First Submitted QC: 2022-03-14
• Study First Posted: 2022-03-15
• Primary Completion: 2024-04-30
• Study Completion: 2024-04-30
• Status Verified: 2024-07
• Last Update Submitted: 2024-07-04
• Last Update Posted: 2024-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Adult patients 19 or older, ASA class I~III,
• scheduled for arthroscopic meniscectomy under general anesthesia and eligible for LMA use.

Exclusion Criteria

• Patient refusal,
• patients unable to read consent form, active URI or uncontrolled asthma,
• pneumonia,
• history of allergies to propofol or benzodiazepines,
• decreased liver or kidney function, heart failure of ejection fraction<55%,
• pregnant or breastfeeding patients,
• history of substance abuse/addiction

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Propofol	Propofol TIVA	Patients receiving general anesthesia with propofol-based total intravenous anesthesia
Remimazolam	Remimazolam TIVA	Patients receiving general anesthesia with remimazolam-based total intravenous anesthesia

Primary Outcome Measures

Name	Time	Method
Quality of Recovery (QoR)-40 questionnaire	Postoperative 24 hours	Quality of recovery assessed with the QoR-40 questionnaire, which is a widely-used, self-rated, self-completed questionnaire for postoperative patients.

Trial Locations

Locations (1)

Yonsei University Health System, Severance Hospital; 🇰🇷 Seoul, Korea, Republic of