Effect of Eating Timing on Body Composition

Not Applicable

• Conditions: Time-Restricted Eating (16:8); Fasting
• Interventions: Other: Time-restricted eating

• Registration Number: NCT03365544
• Lead Sponsor: Western University, Canada

Brief Summary

This study will examine the effect of eating timing on body composition. Previous studies have shown that restricting food intake to 8 hours a day can result in losses in body fat and an up-regulation of fat use. The purpose of this study is to assess changes in body composition when the eating window time is from 6am-2pm vs 2pm-10pm.

Hypothesis: The 2-10pm eating window will result in significantly greater changes in body composition (i.e. decreased fat mass) and the 2pm-10pm window will result in better adherence.

Methods: Body composition (fat and lean mass) will be assessed by air displacement densitometry (Bod Pod). Measures will be made over 4 weeks (pre-) and (post) dietary treatment. Adherence will also be assessed by a questionnaire to determine the ease/difficulty of the treatment.

Detailed Description

Purpose The purpose of the study is to determine whether the eating window of a time-restricted eating protocol affects changes in body composition. It is hypothesized that the afternoon group will have better adherence to their experimental protocol and have greater changes in body composition.

Sample The sample will include 20 healthy adult participants ranging in age from 18-25 that volunteer to participate in the study. Participants will be required to have a body mass index above 26 (BMI=weight(kg)/height(m)2). All individuals must give written informed consent in order to participate in the study. Exclusion criteria include a history of intermittent fasting in the past 6 months, diabetes, or pregnancy and BMI less than 25.9.

Procedure Inclusion/exclusion criteria will be explicitly stated throughout the recruitment process. Potential participants will be recruited through advertising using posters placed through the University of Westerns campus as well as via presentations in classrooms (using the information from the advertising flyers). Individuals who email Bryce Knapp will be invited to a meeting to discuss the study. After the evaluation and information meeting, the individual will be given up to 3 days to determine if they want to participate and give their informed consent. See attached form in the consent section of the ethics application.

Measurement: All individuals will have their body composition measured. Body composition will be measured using air displacement densitometry "Bod Pod". Measurements will be taken twice prior to the intervention and twice on successive days post-intervention. Individuals will also be asked to fill out a biweekly modified dialysis diet and fluid non-adherence questionnaires (DDFQ) with added checkboxes to record which days they complied with the required protocol and 2 questions regarding any struggles the participants experienced. This will be used to assess the adherence to the protocols.

Protocol: 20 participants matched for BMI will be assigned to one of two groups. The two groups will be assigned an eating period of 6am-2pm or 2pm-10pm and instructed not to ingest calories outside of their respective eating window. The interventions will last 4 weeks with individuals being asked to comply to their eating window a minimum of 5 days per week. This will be measured using the modified DDFQ. All testing will be completed by Bryce Knapp under the supervision of Dr. Lemon. The changes in fat mass will be analyzed using a 2-way ANOVA and the adherence will be measured using an independent t-test.

Study Timeline

• Study First Submitted: 2017-11-27
• Status Verified: 2017-12
• Study First Submitted QC: 2017-12-01
• Last Update Submitted: 2017-12-01
• Study First Posted: 2017-12-07
• Last Update Posted: 2017-12-07
• Study Start: 2018-01
• Primary Completion: 2018-02
• Study Completion: 2018-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• 18-25 years of age
• men and women

Exclusion Criteria

• Body mass index less than 26
• No history of intermittent fasting in the past 6 months
• No participants with diabetes
• Are pregnant or become pregnant (self-reported)
• Have symptoms or take medication for a respiratory, cardiovascular, neuromuscular, or metabolic disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
6am-2pm eating window	Time-restricted eating	4 weeks of time restricted eating between 6am-2pm.
2pm-10pm eating window	Time-restricted eating	4 weeks of time restricted eating between 2pm-10pm.

Primary Outcome Measures

Name	Time	Method
Change in Fat mass using "Bod Pod"	4 weeks	Measuring the change in fat mass between the two groups using air displacement densitometry "Bod Pod"

Secondary Outcome Measures

Name	Time	Method
Adherence using the dialysis diet and fluid non-adherence questionnaire.	4 weeks	Measuring adherence of the two groups using the DDFQ non adherence questionaire

Trial Locations

Locations (1)

Exercise Nutrition Laboratory (Western University); 🇨🇦 London, Ontario, Canada