Postoperative Analgesic Efficacy of Modified TAPA and QL Blocks in Laparoscopic Cholecystectomies

Not Applicable

Completed

• Conditions: Nerve Blocks; Cholecystectomy; Postoperative Pain Management; Analgesia; Postoperative Pain

• Registration Number: NCT06540586
• Lead Sponsor: Gaziosmanpasa Research and Education Hospital

Brief Summary

Comparison of Postoperative Analgesic Effects of M-TAPA and Anterior Quadratus Lumborum Blocks in Laparoscopic Cholecystectomies.

Detailed Description

In trunk blocks, the interfascial area between the anterior abdominal wall or back muscles is targeted. Local anesthetics are used for this purpose. Since there is no blood circulation and vascularization in the interfascial areas, the absorption of local anesthetics is slow, providing long-lasting analgesia. Therefore, they are used as a part of multimodal analgesia. The effectiveness of trunk blocks can vary depending on the patient's anatomical differences and previous surgeries, but on average, analgesic effectiveness lasts for 8-12 hours. Sometimes analgesic effectiveness extending up to 24 hours has been reported.

In laparoscopic cholecystectomy operations, pain plays a role in postoperative atelectasis, pneumonia due to atelectasis, prolonged hospital stay, and discharge. To reduce the use of opioids due to their side effects such as nausea, vomiting, itching, constipation, and addiction, opioid-free analgesia is applied, and regional techniques are used. Quadratus lumborum blocks and M-TAPA blocks have been safely and easily applied in abdominal surgery in recent years thanks to developments in trunk blocks and ultrasound technology, and they are frequently preferred.

Study Timeline

• Study Start: 2024-05-01
• Study First Submitted: 2024-08-02
• Study First Submitted QC: 2024-08-02
• Study First Posted: 2024-08-06
• Primary Completion: 2024-10-01
• Study Completion: 2024-10-01
• Status Verified: 2025-07
• Last Update Submitted: 2025-07-09
• Last Update Posted: 2025-07-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

• scheduled for elective Laparoscopic chplecystectomy
• Patients aged ≥18 years
• American Society of Anesthesiologists physical status (ASA) Ⅰ-II

Exclusion Criteria

ASA III-IV patient

• local anesthetic allergy
• Infection at the procedure site Body Mass Index >35 kg/m2 Anticoagulant use with bleeding disorder Chronic analgesia and opioid use with mental and psychiatric disorders Contraindications to regional anesthesia several lung and heart disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Total amount of opioid requirements	within 24 hours after the surgery	The total tramadol use of the patients in 24 hours will be recorded.

Secondary Outcome Measures

Name	Time	Method
rescue analgesia	within 24 hours after the surgery	The rescue analgesia requirement and time of the need of the rescue analgesia requirement

Trial Locations

Locations (1)

Gaziosmanpasa Research and Education Hospital; 🇹🇷 Istanbul, Turkey