Effect of broccoli seedlings on postprandial inflammation and insulin sensitivity

Completed

• Conditions: carbohydrates hyperglycemia; 10018424

• Registration Number: NL-OMON37048
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

healthy men

Exclusion Criteria

Clinical singificant abnormalities at medical research
Diabetes mellitus

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Postprandial inflammation will be tested by measuring nuclear NF-*B abundance<br /><br>in peripheral blood mononuclear cells and by measuring plasma cytokine<br /><br>concentrations. In addition, postprandial insulin sensitivity will be<br /><br>determined by measuring plasma concentrations of glucose and insulin as well as<br /><br>glucose uptake in peripheral tissues using dual isotope labelling. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Evaluate the effect of BroccoCress on insulin sensitivity after a 2nd glucose<br /><br>load<br /><br>Monitor the bioavailability and kinetics of SFN and related metabolites in<br /><br>blood and urine</p><br>